Fig. 4

Forest plot of overall survival by subgroup* after sIPTW. Dx, diagnosis; ECOG PS, Eastern Cooperative Oncology Group performance status; LET, letrozole; ND, not documented; PAL, palbociclib; sIPTW, stabilized inverse probability of treatment weighting. *Race by Cohort interaction and Metastatic Sites by Cohort interaction were the only subgroup variable-by-treatment cohort interaction that were significant (P<0.0001 and P=0.0050, respectively); however, race data were not known in the “not documented” race group.^†Bone-only disease was defined as metastatic disease in the bone only.^‡Visceral disease was defined as metastatic disease in the lung and/or liver; patients could have had other sites of metastases. No visceral disease was defined as no lung or liver metastases. The total patient population for different subgroups varied due to the application of sIPTW. Therefore, the total n number for each subgroup may not have always equaled the N number of the treatment arm (due to rounding error and categorization differences)