Table 1 Morphological features of MCF10A_DCIS orthotopic xenograft lesions

Time of tissue harvest post-implantation (weeks)

2

5

8

Number of fat pads injected (N)

4

6

10

Histologically confirmed DCIS/fat pads examined

2/4

6/6

10/10

 Solid

2/2

4/6

2/6

 Cribriform

0/2

3/6

2/6

 Comedo

0/2

2/6

6/6

Mixed DCIS (at least two types/specimen)

0/2

4/6

2/6

Associated invasive carcinoma

0/2

2/6

4/6