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Table 3 Cox regression analyses for breast cancer-specific survival. Primary tumor

From: Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Variable

HR

(95% CI)

P value

HR

(95% CI)

P value

 

Univariable

Multivariable

Tumor size

 ≤20 vs >20

1,49

(1.14 - 1.96)

0,004

1,41

(0.94 - 2.12)

0,094

NHG

 1, 2 vs 3

1,61

(1.14 - 2.28)

0,007

1,65

(1.07 - 2.53)

0,023

Nodal metastasis

 - vs +

1,51

(1.13 - 2.02)

0,006

2,01

(1.30 - 3.10)

0,002

ER

 - vs +

0,42

(0.27 - 0.63)

0,000

0,57

(0.34 - 0.97)

0,038

CD3

 low vs high

2,34

(1.40 - 3.91)

0,001

1,39

(0.77 - 2.50)

0,28

FOXP3

 low vs high

1,64

(1.39 - 2.37)

0,008

1,72

(1.14 - 2.59)

0,010

  1. Abbreviations: HR hazard ratio, CI confidential interval, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor. CD3 indicates infiltration level of T lymphocytes (low 0, 1, 2 vs high 3) in primary tumor. FOXP3 indicates infiltration level of regulatory T lymphocytes (low 0 vs high 1, 2, 3). Spearman correlation, two-tailed P value. Bold indicates P value < 0.05