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Table 3 Cox regression analyses for breast cancer-specific survival. Primary tumor

From: Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Variable HR (95% CI) P value HR (95% CI) P value
  Univariable Multivariable
Tumor size
 ≤20 vs >20 1,49 (1.14 - 1.96) 0,004 1,41 (0.94 - 2.12) 0,094
NHG
 1, 2 vs 3 1,61 (1.14 - 2.28) 0,007 1,65 (1.07 - 2.53) 0,023
Nodal metastasis
 - vs + 1,51 (1.13 - 2.02) 0,006 2,01 (1.30 - 3.10) 0,002
ER
 - vs + 0,42 (0.27 - 0.63) 0,000 0,57 (0.34 - 0.97) 0,038
CD3
 low vs high 2,34 (1.40 - 3.91) 0,001 1,39 (0.77 - 2.50) 0,28
FOXP3
 low vs high 1,64 (1.39 - 2.37) 0,008 1,72 (1.14 - 2.59) 0,010
  1. Abbreviations: HR hazard ratio, CI confidential interval, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor. CD3 indicates infiltration level of T lymphocytes (low 0, 1, 2 vs high 3) in primary tumor. FOXP3 indicates infiltration level of regulatory T lymphocytes (low 0 vs high 1, 2, 3). Spearman correlation, two-tailed P value. Bold indicates P value < 0.05