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Table 2 Cox regression analyses for recurrence-free survival. Primary tumor

From: Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Variable HR (95% CI) P value HR (95% CI) P value
  Univariable Multivariable
Tumor size
 ≤20 vs >20 1,52 (1.19 - 1.93) 0,001 1,39 (0.98 - 1.98) 0,068
NHG
 1, 2 vs 3 1,62 (1.19 - 2.19) 0,002 1,55 (1.07 - 2.25) 0,021
Nodal metastasis
 - vs + 1,31 (1.02 - 1.69) 0,035 1,71 (1.18 - 2.47) 0,005
ER
 - vs + 0,50 (0.33 - 0.74) 0,000 0,60 (0.37 - 0.97) 0,037
CD3
 low vs high 2,61 (1.57 - 4.32) 0,000 1,77 (1.01 - 3.13) 0,048
FOXP3
 low vs high 1,26 (0.91 - 1.74) 0,16    
  1. Abbreviations: HR hazard ratio, CI confidential interval, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor. CD3 indicates infiltration level of T lymphocytes (low 0, 1, 2 vs high 3) in primary tumor. FOXP3 indicates infiltration level of regulatory T lymphocytes (low 0 vs high 1, 2, 3). Spearman correlation, two-tailed P value. Bold indicates P value < 0.05