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Table 1 Correlation between T lymphocyte (CD3+) and regulatory T cell (FOXP3+) infiltration and clinicopathological features in primary breast cancer

From: Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Variable

N (%)

CD3 infiltration

R

P

N (%)

FOXP3 infiltration

R

P

  

0

1

2

3

   

0

1

2

3

  

All

175 (100)

37

70

48

20

  

176 (100)

67

66

39

4

  

Age

 < 50

79 (45.1)

15

36

22

6

0,04

0,60

81 (46.0)

30

29

19

3

-0,05

0,54

 ≥ 50

96 (54.9)

22

34

26

14

  

95 (54.0)

37

37

20

1

  

Tumor size

 ≤ 20 mm

73 (41.7)

17

28

20

8

0,03

0,71

73 (41.5)

30

27

15

1

0,06

0,42

 > 20 mm

102 (58.2)

20

42

28

12

  

102 (58.0)

37

38

24

3

  

Nodal metastasis

 -

57 (32.6)

13

22

17

5

0,03

0,74

57 (32.4)

16

26

13

2

-0,10

0,18

 +

114 (65.1)

24

45

31

14

  

116 (65.9)

48

40

26

2

  

Ki67

 -

108 (61.7)

28

47

23

10

0,21

0,01

109 (61.9)

52

38

18

1

0,33

0,000

 +

59 (33.7)

9

19

21

10

  

58 (33.0)

10

25

20

3

  

NHG

 Grade 1/2

62 (35.4)

12

31

16

3

0,06

0,43

64 (36.4)

27

24

13

0

0,06

0,48

 Grade 3

91 (52.0)

22

32

24

13

  

91 (51.7)

34

36

17

4

  

ER

 -

33 (18.9)

6

9

10

8

-0,16

0,04

32 (18.2)

8

11

12

1

-0,17

0,03

 +

138 (78.9)

31

59

36

12

  

139 (79.0)

56

54

26

3

  

PR

 -

74 (42.3)

18

23

20

13

-0,08

0,29

72 (40.9)

25

27

19

1

-0,07

0,39

 +

96 (54.9)

19

45

26

6

  

98 (55.7)

39

38

18

3

  

Luminal A

59 (33.7)

14

29

12

4

-0,17

0,03

60 (34.1)

32

20

7

1

-0,30

0,000

Luminal B

72 (41.1)

15

26

23

8

0,04

0,65

72 (40.9)

18

33

19

2

0,17

0,03

HER2

9 (5.1)

2

2

1

4

0,10

0,20

8 (4.5)

2

5

1

0

0,00

0,96

TN

22 (12.6)

3

7

9

3

0,11

0,16

22 (12.5)

5

6

10

1

0,18

0,02

  1. Abbreviations: N number of patients included in analysis, R correlation coefficient, Ki67 proliferation marker, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor, TN triple negative. Spearman correlation, two-tailed P value. Bold indicates P value < 0.05