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Table 1 Correlation between T lymphocyte (CD3+) and regulatory T cell (FOXP3+) infiltration and clinicopathological features in primary breast cancer

From: Regulatory T lymphocyte infiltration in metastatic breast cancer—an independent prognostic factor that changes with tumor progression

Variable N (%) CD3 infiltration R P N (%) FOXP3 infiltration R P
   0 1 2 3     0 1 2 3   
All 175 (100) 37 70 48 20    176 (100) 67 66 39 4   
Age
 < 50 79 (45.1) 15 36 22 6 0,04 0,60 81 (46.0) 30 29 19 3 -0,05 0,54
 ≥ 50 96 (54.9) 22 34 26 14    95 (54.0) 37 37 20 1   
Tumor size
 ≤ 20 mm 73 (41.7) 17 28 20 8 0,03 0,71 73 (41.5) 30 27 15 1 0,06 0,42
 > 20 mm 102 (58.2) 20 42 28 12    102 (58.0) 37 38 24 3   
Nodal metastasis
 - 57 (32.6) 13 22 17 5 0,03 0,74 57 (32.4) 16 26 13 2 -0,10 0,18
 + 114 (65.1) 24 45 31 14    116 (65.9) 48 40 26 2   
Ki67
 - 108 (61.7) 28 47 23 10 0,21 0,01 109 (61.9) 52 38 18 1 0,33 0,000
 + 59 (33.7) 9 19 21 10    58 (33.0) 10 25 20 3   
NHG
 Grade 1/2 62 (35.4) 12 31 16 3 0,06 0,43 64 (36.4) 27 24 13 0 0,06 0,48
 Grade 3 91 (52.0) 22 32 24 13    91 (51.7) 34 36 17 4   
ER
 - 33 (18.9) 6 9 10 8 -0,16 0,04 32 (18.2) 8 11 12 1 -0,17 0,03
 + 138 (78.9) 31 59 36 12    139 (79.0) 56 54 26 3   
PR
 - 74 (42.3) 18 23 20 13 -0,08 0,29 72 (40.9) 25 27 19 1 -0,07 0,39
 + 96 (54.9) 19 45 26 6    98 (55.7) 39 38 18 3   
Luminal A 59 (33.7) 14 29 12 4 -0,17 0,03 60 (34.1) 32 20 7 1 -0,30 0,000
Luminal B 72 (41.1) 15 26 23 8 0,04 0,65 72 (40.9) 18 33 19 2 0,17 0,03
HER2 9 (5.1) 2 2 1 4 0,10 0,20 8 (4.5) 2 5 1 0 0,00 0,96
TN 22 (12.6) 3 7 9 3 0,11 0,16 22 (12.5) 5 6 10 1 0,18 0,02
  1. Abbreviations: N number of patients included in analysis, R correlation coefficient, Ki67 proliferation marker, NHG Nottingham histologic grade, ER estrogen receptor, PR progesterone receptor, TN triple negative. Spearman correlation, two-tailed P value. Bold indicates P value < 0.05