Table 1 Gene lists based on various selection criteria from the 43 DEGs in COX-2 high patients
Selection criteria | High genetic alteration in TCGA-TNBC patients (GL1) | High genetic alteration in MBC patients (GL2) | High mRNA expression in PAM50 basal BC patients (GL3) | High Mrna expression in TNBC patients (GL4) | High expression correlates with poor survival outcomes (GL5) | High expression in COX-2 inhibitor-resistant BC cell lines (GL6) |
|---|---|---|---|---|---|---|
Gene symbol | MDFI EPHB3 FBXO32 MSN SFRP1 ID4 ACTN4 TNFRSF21 MFGE8 TFAP2C RGS2 ITGB4 SLC44A2 ITGA6 S100B KLK7 DEGS1 GNAS PTGS2 LAMC2 KLK5 TACSTD2 SLC2A1 CTNNB1 KLK6 CD55 TPM4 FURIN RBP1 KRT6B PPP1R1B SERPINB5 | FBXO32 PPP1R1B THBS1 LAMC2 STAC2 ATP1B1 DEGS1 IER3 OGFRL1 GNAS TFAP2C CD55 SFRP1 ITGB4 MFGE8 EPHB3 ACTN4 RGS2 PTGS2 SLC2A1 COL9A2 DSP MDFI PTP4A1 TNFRSF21 ID4 FURIN CTNNB1 KLK7 TPM4 TACSTD2 FBLN2 SERPINB5 KLK5 KLK6 RBP1 | TPM4 TNFRSF21 RGS2 TFAP2C ITGA6 COL9A1 SFRP1 FURIN LAMC2 TACSTD2 MSN S100B FBXO32 STAC2 DSP KRT6B SERPINB5 ITGB4 FOXI1 EPHB3 MDFI KLK7 OGFRL1 MFGE8 ACTN4 KLK5 SLC44A2 KLK6 ID4 RBP1 PTP4A1 TMX4 SLC2A1 GNAS | TPM4 TNFRSF21 RGS2 TFAP2C ITGA6 SFRP1 FURIN LAMC2 CD55 MSN S100B FBXO32 STAC2 KRT6B FBLN2 SERPINB5 ITGB4 EPHB3 MDFI KLK7 OGFRL1 MFGE8 ACTN4 KLK5 SLC44A2 KLK6 ID4 RBP1 TMX4 SLC2A1 GNAS | TPM4 RGS2 TFAP2C ITGA6 ATP1B1 LAMC2 CD55 TACSTD2 CTNNB1 KRT6B SERPINB5 IER3 ITGB4 KLK7 MFGE8 KLK5 ID4 RBP1 PTP4A1 SLC2A1 | TPM4 RGS2 COL9A2 SFRP1 LAMC2 FBLN2 SERPINB5 KLK7 MFGE8 KLK5 ID4 RBP1 SLC2A1 |