Skip to main content
Fig. 1 | Breast Cancer Research

Fig. 1

From: FGFR1 amplification or overexpression and hormonal resistance in luminal breast cancer: rationale for a triple blockade of ER, CDK4/6, and FGFR1

Fig. 1

Concordance between FGFR1 amplification and overexpression and prognostic impact among hormone-positive breast cancer patients. Kaplan-Meier curves representing the impact of FGFR1-amplficiation disease relapse risk in the general HR+ breast cancer cohort (a) or split according to the Lum-A or Lum-B subtypes (b) in the discovery set (H12O series) or in the METABRIC Lum-A/B cohort (c) and (d). e Left panel: concordance between the result of FGFR1 FISH and RNAscope tests. Right panel: examples of concordant results (positive or negative in both tests) or non-concordant results (positive/negative or vice versa) in different cases of the H12O series. f, g Same as a and b according to RNAscope positivity. h Kaplan-Meier curve for distant relapse of patients with FGFR1 amplification and/or FGFR1 mRNA overexpression compared to non-amplified, non-overexpressed cases. Patients at risk are stated under each Kaplan-Meier curve. Vertical ticks represent censoring events

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us