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Table 6 Prognostic values of changes in body mass index within the first 2 years since diagnosis: multivariable Cox models

From: Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients

  Overall survival Breast cancer-specific survival Disease-free survival
Events/persons HR (95% CI)* P Events/persons HR (95% CI)* P Events/persons HR (95% CI)* P
Slope in the first 2 years after diagnosis
 Loss > 0.5 kg/m2/year 113/680 1.69 (1.20–2.40) 0.003 60/680 2.00 (1.20–3.34) 0.008 129/659 1.54 (1.13–2.11) 0.007
 Stable (≤ 0.5 kg/m2/year) 57/804 1.0 (ref.)   25/804 1.0 (ref.)   72/786 1.0 (ref.)  
 Gain > 0.5 kg/m2/year 59/775 1.10 (0.74–1.63) 0.63 32/775 1.26 (0.72–2.22) 0.42 86/757 1.16 (0.83–1.63) 0.39
Change from diagnosis to 18 months
 Loss > 5% 65/356 1.60 (1.11–2.31) 0.012 38/356 1.63 (0.99–2.69) 0.053 65/346 1.33 (0.95–1.88) 0.099
 Stable (≤ 5%) 82/1127 1.0 (ref.)   40/1127 1.0 (ref.)   109/1106 1.0 (ref.)  
 Gain > 5% 27/311 1.14 (0.72–1.81) 0.58 13/311 0.95 (0.49–1.84) 0.89 37/306 1.05 (0.70–1.57) 0.81
  1. *Adjusted for age, race, Carlson comorbidity index, tumor stage, histologic grade, molecular subtype, radiotherapy, hormonal therapy, and chemotherapy in delayed entry Cox models
  2. Abbreviations: HR hazard ratio, CI confidence intervals