Fig. 2

DOTBIS bilateral measurements were acquired at six or three different time points depending on the NAC regimen. For patients under T × 12/AC × 4 and T/C × 12/AC × 4 therapies (n = 69), contralateral non-tumor-bearing breast and the breast bearing the tumor were imaged at baseline (TP0), 2 weeks after the first taxane infusion (TP1), after four infusions of taxane (TP2), at the end of the taxane regimen and before starting AC cycle (TP3), after two AC infusions (TP4), and at the end of NAC and before surgery (TP5). For other taxane-based NAC regimens (n = 36), both breasts were imaged only three times: TP0, 2–3 weeks after the first taxane infusion (TP1), and TP5