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Table 2 Adjusted hazard ratios for breast cancer death by IHC subtypes, grade and pTN

From: In modern times, how important are breast cancer stage, grade and receptor subtype for survival: a population-based cohort study

IHC subtype

Grade

Patients (N)/deaths (n)

pT1pN0

pT2pN0

pT1-2pN+

pT3-4pN0/+

pT1pN0

pT2pN0

pT1-2pN+

pT3-4pN0/+

N/n

N/n

N/n

N/n

HR [95% CI]

HR [95% CI]

HR [95% CI]

HR [95% CI]

ER+PR+HER2−

I

2498/17

225/7

592/22

30/2

1.0 [ref]

3.6 [1.5, 8.6]

4.2 [2.2, 7.9]

6.3 [1.5, 27.5]

II

3175/36

805/23

1892/117

149/25

1.6 [0.9, 2.8]

3.6 [1.9, 6.7]

7.3 [4.4, 12.2]

15.5 [8.3, 28.9]

III

556/25

332/24

641/83

51/16

6.4 [3.4, 11.8]

10.5 [5.6, 19.7]

16.7 [9.9, 28.2]

39.8 [20.0, 79.6]

ER+PR−HER2−

I

445/2

30/1

80/5

8/0

0.7 [0.2, 2.9]

4.3 [0.6, 32.5]

7.9 [2.9, 21.5]

N/A

II

650/16

173/10

377/50

37/8

3.3 [1.7, 6.6]

7.5 [3.4, 16.4]

14.3 [8.2, 24.9]

24.8 [10.6, 57.9]

III

214/11

158/16

237/46

15/3

8.5 [4.0, 18.2]

16.2 [8.2, 32.2]

24.5 [14.0, 42.9]

22.3 [6.5, 76.4]

ER+PR+HER2+/ER+PR−HER2+a

II

376/6

114/5

266/21

23/2

2.1 [0.8, 5.3]

6.0 [2.2, 16.2]

8.5 [4.4, 16.1]

7.6 [1.7, 32.8]

III

286/12

149/12

344/26

14/3

5.6 [2.7, 11.7]

11.1 [5.3, 23.3]

9.3 [5.0, 17.2]

21.3 [6.2, 73.1]

HER2pos

II

82/1

21/1

63/7

5/2

1.3 [0.2,9.4]

7.2 [1.0, 53.8]

12.9 [5.3, 31.2]

44.5 [10.2,193.5]

III

168/10

110/8

247/28

30/8

6.7 [3.1, 14.6]

9.2 [3.9, 21.3]

12.8 [7.0, 23.4]

27.6 [11.9, 64.4]

TNBC

II

150/6

45/7

59/12

6/3

4.8 [1.9, 12.1]

17.8 [7.4, 43.1]

22.3 [10.6, 46.8]

86.9 [25.4, 297.5]

III

488/34

368/40

393/80

27/8

9.2 [5.1, 16.5]

14.4 [8.2, 25.5]

25.8 [15.2, 43.7]

28.5 [12.2, 66.5]

  1. Hazard ratios adjusted for age and year of diagnosis, subtype × grade × pTN status interaction, surgery type and follow-up. Restricted to M0. N = 17,204. Test of interaction: 3-way interaction IHC subtype × grade × pTN status vs. IHC subtype × grade + pTN status, p = 0.4333. Test of interaction: 2-way interaction IHC subtype × grade + pTN status vs. IHC subtype + grade + pTN status, p = 0.0022
  2. HER2pos ER−PR−HER2+, TNBC ER−PR−HER2−
  3. aER+PR+HER2+ and ER+PR−HER2+ combined into one category