Fig. 2From: RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancerRANK, but not RANKL, expression increased after dual anti-HER2 therapy in patient samples (n = 151) from the PAMELA trial. a Box plots of RANK and RANKL gene expression in HER2-positive tumors at baseline classified by hormone receptor expression. b Ladder plots (on the left) show the RANK and RANKL gene expression in PAMELA HER2-positive tumors before (baseline) and after (surgery) dual anti-HER2 treatment. An increase in gene expression is represented in red and a decrease in blue. Each line represents a tumor sample from one patient. p values in a were calculated by comparing the mean values between both groups and in b were determined by paired two-tailed t tests. Density plots (on the right) showing the RANK and RANKL gene expression in PAMELA HER2-positive tumors before (baseline) and after (surgery) treatment (see Fig. S3, S4, and Supplementary Table 1 for further analyses)Back to article page