Table 2 Difference in frailty and immune cell profiles pre-, post-, and 6 months post-chemotherapy
|  | Pre-chemo N (%) | Post-chemo N (%) | 6 months post-chemo N (%) | Pre- vs post-chemo (p value) | Pre- vs 6 months post-chemo (p value) |
|---|---|---|---|---|---|
Frailty components | |||||
 Weakness ≥ 4 | 145 (25.0) | 290 (54.3) | 153 (30.2) | < 0.001 | 0.056 |
 Exhaustion ≥ 4 | 230 (39.7) | 342 (63.9) | 214 (42.3) | 0.008 | 0.378 |
 Walk speed < 2 mph | 313 (54.5) | 353 (66.6) | 254 (50.7) | < 0.001 | 0.210 |
 Physical activity < 150 min/week | 53 (9.2) | 76 (14.3) | 30 (6.0) | 0.008 | 0.049 |
Frailty score: N (%) | |||||
 0 | 173 (29.8) | 74 (13.8) | 154 (30.4) | < 0.001 | 0.480 |
 1 | 195 (33.6) | 122 (22.8) | 151 (29.8) | ||
 2 | 109 (18.8) | 124 (23.1) | 115 (22.7) | ||
 3 | 88 (15.2) | 173 (32.3) | 74 (14.6) | ||
 4 | 16 (2.8) | 43 (8.0) | 12 (2.37) | ||
 Mean [SD] | 1.3 [1.1] | 2.0 [1.2] | 1.3 [1.1] | < 0.001 | 0.846 |
Cell counts: mean [SD] | |||||
 Neutrophils (103 cells/μL) | 4.69 [2.68] | 4.84 [5.01] | – | 0.560 | – |
 Lymphocytes (103 cells/μL) | 1.88 [0.97] | 1.22 [1.48] | – | < 0.0001 | – |
 Monocytes (103 cells/μL) | 0.53 [0.55] | 0.54 [0.53] | – | 0.947 | – |
 NLR | 3.00 [2.98] | 5.03 [5.71] | – | < 0.001 | – |
 LMR | 5.72 [31.2] | 2.8 [1.98] | – | 0.038 | – |
 Total WBC (103 cells/μL) | 7.42 [3.05] | 6.59 [4.76] | – | < 0.001 | – |
 Hemoglobin (g/dL) | 12.67 [2.28] | 11.12 [1.58] | – | < 0.001 | – |
 Hematocrit (%) | 37.50 [6.92] | 33.26 [4.65] | – | < 0.001 | – |
 Platelets (103 cells/μL) | 260.27 [81.82] | 237.93 [89.16] | – | < 0.001 | – |
 Albumin (g/dL) | 4.17 [0.43] | 3.93 [0.47] | – | < 0.001 | – |