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Fig. 6 | Breast Cancer Research

Fig. 6

From: Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis

Fig. 6

Serum exo-AnxA2 promotes angiogenesis. a Representative images of Matrigel plugs containing serum exosomes derived from non-cancer, ER+, HER2+, TNBC breast subtypes, and their impact on angiogenesis. b Quantification of angiogenesis formation through hemoglobin estimation by Drabkin’s method (n = 3; ****, P < 0.0001; one-way ANOVA followed by Tukey’s multiple comparison test). c Representative images of Matrigel plugs containing serum exosomes derived from AA and CA TNBC patients that show comparison of angiogenesis between AA and CA TNBC patients. LCKLSL (AnxA2 inhibitory peptide) and LGKLSL (control peptide) were used to demonstrate the functional role of AnxA2 in contributing to angiogenesis. Peptide concentration: 5 μmol/L. d Quantification of angiogenesis formation through hemoglobin estimation by Drabkin’s method (n = 3; **, P < 0.01; ****, P < 0.0001; one-way ANOVA followed by Tukey’s multiple comparison test)

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