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Fig. 2 | Breast Cancer Research

Fig. 2

From: Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis

Fig. 2

Exo-AnxA2 analysis in serum samples of breast cancer patients and non-cancer females. a Scatter plot analysis of exo-AnxA2 protein concentration obtained through ELISA analysis from serum of non-cancer (n = 68) females and breast cancer (n = 169) patients. Each point represents the mean of triplicates. The data are expressed as the mean ± SEM (****, P < 0.0001; two-tailed Student’s t test). b Matrigel plug assay with serum exosomes derived from non-cancer females and breast cancer patients along with incubation with LCKLSL AnxA2 inhibitory or LGKLSL control peptides was performed in athymic nude mice (n = 3). Representative images of the Matrigel plugs are shown. Peptide concentration: 5 μmol/L. c Quantification of hemoglobin estimation of homogenized Matrigel plugs from non-cancer and breast cancer serum exosomes by Drabkin’s method (n = 3; *, P < 0.05; ****, P < 0.0001; one-way ANOVA followed by Tukey’s multiple comparison test)

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