Fig. 3

Forest plots of all methylation markers reported in two or more independent study populations. HRs with a statistically significant association are depicted with a solid line; HRs of reported markers with no significant association are depicted with a dotted line; univariate HRs (^a) and confidence intervals (CI) are reported unless multivariate HRs (^b) were available. Per marker, if results are derived from the same cohort, but with differing characteristics, such as differing DNA origin or location of methylation, this is represented by a coloured population bar. Per marker, if results originated from the same research group, this is indicated by an asterisk (*). Due to the vast number of individual results for these markers, for visualisation purposes, per marker, this figure shows one result per investigated population and tissue type. For a full representation of markers reported in two or more independent study populations, see Additional file 5: Table S5