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Table 3 Association between RRSO and breast cancer risk

From: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

 

BRCA1 mutation carriers

BRCA2 mutation carriers

Person-years

BC

HR

95% CI

Person-years

BC

HR

95% CI

No RRSO

8353

154a

1.00

–

5769

106b

1.00

–

RRSO at any age (years)

3988

115a

1.23

0.94–1.61

2117

51b

0.88

0.62–1.24

 ≤ 45

2205

64

1.19

0.88–1.61

964

17

0.68

0.40–1.15

 > 45

1783

51

1.34

0.89–2.02

1153

34

1.07

0.69–1.64

Time since RRSO (years)

 < 2

1111

40

1.43

1.01–2.03

694

24

1.29

0.82–2.02

 2–5

1261

32

1.06

0.71–1.57

722

17

0.82

0.48–1.38

 > 5

1616

43

1.18

0.81–1.71

701

10

0.51

0.26–0.99

  1. A Cox regression model was used adjusting for country, stratified by year of birth (≤ 1960, ≥ 1961) and with robust standard errors (clustering by family)
  2. BC breast cancer, RRSO risk-reducing salpingo-oophorectomy, HR hazard ratio
  3. aAmong BRCA1 mutation carriers, tumour pathology was unknown for 5 women without RRSO and 9 following RRSO
  4. bAmong BRCA2 mutation carriers, tumour pathology was unknown for 12 women without RRSO and 7 following RRSO
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Breast Cancer Research

ISSN: 1465-542X

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