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Table 2 Characteristics of the cohort of BRCA1 and BRCA2 mutation carriers

From: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

 

BRCA1 mutation carriers

BRCA2 mutation carriers

Unaffected women (N = 2003)

Women with breast cancer (N = 269)

Unaffected women (N = 1448)

Women with breast cancer (N = 157)

Total person-years of follow-up

11,207

1134

7286

600

Person-years of follow-up (mean (sd))

5.60 (3.67)

4.21 (3.27)

5.03 (3.44)

3.82 (3.08)

Age at start of follow-up (mean (sd))

37.51 (11.80)

40.68 (10.25)

40.00 (12.53)

45.14 (10.11)

Age at diagnosis/censoring (mean (sd))

43.10 (12.28)

44.90 (10.33)

45.00 (13.00)

48.97 (10.30)

Reason for censoring

 Breast cancer

0

269

0

157

 Ovarian cancer

49

3a

9

1a

 Other cancer

45

5a

28

2a

 RRM

299

–

181

–

 Death

5

–

8

–

 Unaffected at last follow-up time

1605

–

1222

–

Year of birth

 ≤ 1960

604 (83.54)

119 (16.46)

500 (84.75)

90 (15.25)

 > 1960

1399 (90.32)

150 (9.68)

948 (93.40)

67 (6.60)

Menopausal status

 Premenopausal at censoringb

    

  Last informationc after censoring

512

69

344

35

  Last information before censoringd

585

58

473

35

 Postmenopausal

  Natural menopause age known

194

27

182

31

  Natural menopause age unknown

5

0

7

1

 Post-hysterectomy

70

12

64

11

 Unknown menopausal status

62

13

33

8

RRSO status at censoring

 No RRSO

  Last information after censoring

664

110

467

79

  Last information before censoring

618

44

535

27

 RRSO

721

115

446

51

  As reason for menopausee

574

90

345

36

  After natural menopause

101

18

76

10

  After hysterectomy

46

7

25

5

  1. RRSO risk-reducing salpingo-oophorectomy, RRM risk-reducing mastectomy
  2. aDiagnosed at the same time as breast cancer
  3. bFifteen women did not report age at menopause but were older than 60 years at the end of follow-up
  4. cInformation from questionnaire and record linkage
  5. dAge last known to be premenopausal mean 32.3 years, median 31 years for BRCA1 mutation carriers: mean 33.9, median 34 years for BRCA2 mutation carriers. Time between this age and end of censoring: mean 6.3, median 5 years for BRCA1 and mean 6 years, median 5 years for BRCA2 mutation carriers
  6. eSeven women reported RRSO after age 60 years without first reporting natural menopause