Fig. 9
From: p66ShcA functions as a contextual promoter of breast cancer metastasis
Distinct intracellular p66ShcA pools collaborate to potentiate breast cancer lung metastasis. Schematic diagram illustrating how both cytoplasmic and mitochondrial p66ShcA pools collaborate to potentiate discrete stages of the metastatic cascade. Altogether, breast cancer cells rely on both mitochondrial and cytoplasmic p66ShcA complexes to increase their lung-metastatic potential