TY - JOUR AU - Lewis, Kyle AU - Kiepas, Alex AU - Hudson, Jesse AU - Senecal, Julien AU - Ha, Jacqueline R. AU - Voorand, Elena AU - Annis, Matthew G. AU - Sabourin, Valerie AU - Ahn, Ryuhjin AU - La Selva, Rachel AU - Tabariès, Sébastien AU - Hsu, Brian E. AU - Siegel, Matthew J. AU - Dankner, Matthew AU - Canedo, Eduardo Cepeda AU - Lajoie, Mathieu AU - Watson, Ian R. AU - Brown, Claire M. AU - Siegel, Peter M. AU - Ursini-Siegel, Josie PY - 2020 DA - 2020/01/15 TI - p66ShcA functions as a contextual promoter of breast cancer metastasis JO - Breast Cancer Research SP - 7 VL - 22 IS - 1 AB - The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the cytoplasm to the mitochondria where it stimulates the formation of reactive oxygen species (ROS). Conflicting studies suggest both pro- and anti-tumorigenic functions for p66ShcA, which prompted us to examine the contribution of tumor cell-intrinsic functions of p66ShcA during breast cancer metastasis. SN - 1465-542X UR - https://doi.org/10.1186/s13058-020-1245-6 DO - 10.1186/s13058-020-1245-6 ID - Lewis2020 ER -