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Table 3 Molecular alterations in 16 cases of PLC from our institution

From: Targetable alterations in invasive pleomorphic lobular carcinoma of the breast

ID ER IHC PR IHC HER2 Gene Alteration Gene Alteration
1 3+ 0 1+ neg PIK3CA H1047L   
2 99% 3+ 50% 2–3+ neg Not detected    
3 0 0 pos fish ERBB2 L755S TP53 S15Rfs*18
4 0 0 neg ERBB2 L755S PIK3CA P539R
5 99% 3+ 99% 3+ neg Not detected    
6 95% 3+ 70% 3+ neg PIK3CA H1047R   
7 95% 3+ 90% 3+ neg Not detected    
8 99% 3+ 99% 3+ neg Not detected    
9 100% 3+ 60% 3+ neg AKT1 E17K   
10 95% 3+ 95% 3+ neg PIK3CA H1047R   
11 95% 3+ 80% 3+ neg Not detected    
12 95% 3+ 90% 3+ neg Not detected    
13 95% 3+ 0 pos ERBB2 E770_A771insAYVM   
14 0 0 pos PIK3CA Q546E TP53 R248Q
15 95% 2–3+ 95% 2–3+ neg PIK3CA E545K TP53 G108S
16 95% 3+ 80% 3+ pos TP53 R175H