Targetable alterations in invasive pleomorphic lobular carcinoma of the breast

Breast Cancer Research

Table 3 Molecular alterations in 16 cases of PLC from our institution

ID	ER IHC	PR IHC	HER2	Gene	Alteration	Gene	Alteration
1	3+	0	1+ neg	PIK3CA	H1047L
2	99% 3+	50% 2–3+	neg	Not detected
3	0	0	pos fish	ERBB2	L755S	TP53	S15Rfs*18
4	0	0	neg	ERBB2	L755S	PIK3CA	P539R
5	99% 3+	99% 3+	neg	Not detected
6	95% 3+	70% 3+	neg	PIK3CA	H1047R
7	95% 3+	90% 3+	neg	Not detected
8	99% 3+	99% 3+	neg	Not detected
9	100% 3+	60% 3+	neg	AKT1	E17K
10	95% 3+	95% 3+	neg	PIK3CA	H1047R
11	95% 3+	80% 3+	neg	Not detected
12	95% 3+	90% 3+	neg	Not detected
13	95% 3+	0	pos	ERBB2	E770_A771insAYVM
14	0	0	pos	PIK3CA	Q546E	TP53	R248Q
15	95% 2–3+	95% 2–3+	neg	PIK3CA	E545K	TP53	G108S
16	95% 3+	80% 3+	pos	TP53	R175H

ISSN: 1465-542X