From: Targetable alterations in invasive pleomorphic lobular carcinoma of the breast
ID | ER IHC | PR IHC | HER2 | Gene | Alteration | Gene | Alteration | Gene | Alteration | Gene | Alteration | Other alterations |
---|---|---|---|---|---|---|---|---|---|---|---|---|
TCGA-AR-A2LJ | 70–79% | 70–75% | pos | CDH1 | E165Q | ERBB2 | AMP | PIK3CA | H1047R |  |  |  |
TCGA-A2-A0SY | 80–89% | 40–49% | pos fish | CDH1 | S18fs | ERBB2 | AMP | PIK3CA | E545K |  |  |  |
TCGA-D8-A27G | > 75% | > 75% | 2 ihc fish neg | CDH1 | E167fs | ERBB2 | AMP/ I767M | PIK3CA | H1047R |  |  |  |
TCGA-A8-A0A7 | neg | neg | pos | CDH1 | E243K | ERBB2 | AMP | PIK3CA | E726K | Â | Â | Â |
TCGA-A8-A0A6 | pos | pos | neg | CDH1 | T522_splice | ERBB2 | L755S | PIK3CA | G118D | Â | Â | Â |
TCGA-A8-A0AB | ? | ? | ? | CDH1 | D400fs | ERBB2 | L755S | PIK3CA | Â | Â | Â | BRCA2 deep del |
TCGA-C8-A274 | ? | ? | ? | CDH1 | P625fs | ERBB2 | I767M | PIK3CA | H1047R | Â | Â | Â |
TCGA-AC-A3YI | 90–99% | 20–29% | neg | CDH1 | E763fs | ERBB2 | L755S | PIK3CA |  |  |  | FGFR1 amp |
TCGA-A2-A0T6 | 90–99% | 90–99% | neg | CDH1 | Y827fs | ERBB2 | L755R (L755W, L755M) & R678Q | PIK3CA |  |  |  |  |
TCGA-BH-A0C1 | pos | pos | neg | CDH1 | P159fs | ERBB2 | V777L | PIK3CA | Â | Â | Â | Â |
TCGA-C8-A3M7 | neg | neg | neg | CDH1 | T340fs | ERBB2 | S305C | PIK3CA | H1047R | Â | Â | KMT2C Q3151* |
TCGA-AO-A128 | neg | neg | neg | CDH1 | A817V | ERBB2 | V797A | PIK3CA | Â | Â | Â | TP53 R342*, KMT2C Q1787Lfs*18 & E495Dfs*42 |
TCGA-BH-A18P | pos | neg | pos | CDH1 | S36fs | ERBB2 | L755S | PIK3CA | Â | Â | Â | MAP3K1 P233Qfs*30 |
TCGA-A8-A07B | pos | pos | pos fish | CDH1 | P200fs | Â | Â | PIK3CA | H1047R | Â | Â | TP53 Q165Afs*8 |
TCGA-E2-A1IJ | ? | ? | ? | CDH1 | V678fs | Â | Â | PIK3CA | Â | PTEN | homodel | Â |
TCGA-A2-A0EX | pos | pos | neg | CDH1 | Q511* | Â | Â | PIK3CA | E545K | Â | Â | FGFR1 amp |
TCGA-E2-A2P5 | pos | pos | neg fish | CDH1 | Q383* | Â | Â | PIK3CA | N345K, G914R | Â | Â | TP53 F341S KMT2C E648Vfs*8 |
TCGA-AR-A2LL | 70–79% | 70–79% | neg fish | CDH1 | G278R |  |  | PIK3CA |  | PTEN | C124S |  |
TCGA-E9-A3X8 | 20–29% | 20–29% | < 10% pos (negative in report) | CDH1 | 515_516ins* |  |  | PIK3CA |  |  |  |  |
TCGA-BH-A0E9 | pos | pos | neg | CDH1 | D756fs | Â | Â | PIK3CA | Â | PTEN | X70_splice | Â |
TCGA-EW-A1J5 | 90–99% | 90–99% | neg | CDH1 | F499fs |  |  | PIK3CA | E545K, E726K |  |  |  |
TCGA-BH-A2L8 | 70–79% | 80–89% | neg | CDH1 | R800fs |  |  | PIK3CA | G1049R | PTEN | S287* |  |
TCGA-BH-A18F | pos | pos | neg | CDH1 | L581fs | Â | Â | PIK3CA | Q546K, H1047R | Â | Â | Â |
TCGA-BH-A209 | pos | pos | ? | CDH1 | R63* | Â | Â | PIK3CA | Â | Â | Â | ZNF791-FGFR1 |
TCGA-A2-A3KC | 90–99% | 90–99% | neg fish | CDH1 | T748fs |  |  | PIK3CA | H1047R |  |  |  |
TCGA-AN-A03Y | pos | pos | neg | CDH1 | R63* | Â | Â | PIK3CA | H1047R | Â | Â | Â |
TCGA-A8-A09W | ? | ? | ? | CDH1 | T646_splice | Â | Â | PIK3CA | Â | Â | Â | RB1 Y606* |
TCGA-EW-A3E8 | ? | ? | ? | CDH1 | I722_splice | Â | Â | PIK3CA | E545K | Â | Â | Â |
TCGA-AO-A12G | 90–99% | 30–39% | neg fish | CDH1 | 16q22.1 homodel |  |  | PIK3CA |  | PTEN | R47fs | TP53 K139_P142del |
TCGA-E2-A1LG | ? | ? | ? | CDH1 | 16q22.1 homodel | Â | Â | PIK3CA | Â | Â | Â | TP53 I255del KMT2c W1002* FGFR1 amp PIK3R2 amp |
TCGA-A2-A25D | ? | ? | ? | CDH1 | 16q22.1 homodel | Â | Â | PIK3CA | E110del | Â | Â | Â |