Table 1 Sample summary and clinical results
| Â | Â | Â | Â | Â | Â | Pre-treatment | Post-treatment | Fold change | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ID | TNM | Ki67 | Grade | ER/PR | HER2 | sTIL H&E (%) | sTIL mIF* (count/pixel) | PD-L1 mIF* (count/pixel) | PD-L1 SP142 | sTIL H&E (%) | sTIL mIF* (count/pixel) | PD-L1 mIF* (count/pixel) | PD-L1 SP142 | sTIL H&E | PD-L1 SP142 |
1 | pT1c, N1 | 11% | 2 | +/+ (100%/100%) | – | 8.75 | 0.48 | 0.07 | IC0 | 12.5 | 0.59 | 0.13 | IC0 | + 0.4 | 0 |
2 | pT2c, pN2 | 19% | 2 | +/+ (96%/90%) | – | 13.75 | 1.35 | 1.04 | IC0 | 20 | 1.53 | 0.87 | n/a | + 0.5 | n/a |
3 | pT2, N1 | 17% | 2 | +/+ (98%/100%) | – | 1.75 | 0.13 | 0.07 | IC0 | 1.75 | 1.25 | 0.35 | IC1 | 0 | + 1 |
4 | pT2N1 | 75% | 3 | −/− (0%/0%) | + | 6.25 | 0.23 | 0.24 | IC1 | 10 | 0.74 | 0.68 | IC2 | + 0.6 | + 1 |
5 | pT1c, N1 | 7% | 1 | +/+ (98%/92%) | – | 3.75 | 0.88 | 0.18 | IC0 | 5 | 0.34 | 0.09 | IC1 | + 0.3 | + 1 |
6 | T2, N1 | 73% | 3 | −/− (0%/0%) | + | 18.75 | 0.84 | 0.01 | IC0 | 18.75 | 0.94 | 0.40 | IC0 | 0 | 0 |
7 | T2, N1 | 55% | 3 | +/+ (98%/100%) | – | 18.75 | 1.18 | 0.54 | IC1 | 20 | 1.24 | 0.64 | n/a | + 0.1 | n/a |
8 | pT2, N0 | 50% | 3 | +/+ (100%/42%) | – | 7.5 | 1.28 | 0.97 | IC1 | 16.25 | 1.68 | 1.30 | IC1 | + 1.2 | 0 |
9 | pT1b, pN0 | 11% | 2 | +/+ (100%/100%) | – | 1 | 0.06 | 0.06 | IC0 | 5 | 0.27 | 0.23 | IC0 | + 4 | 0 |
10 | T1c, N0 | 33% | 2 | +/+ (100%/99%) | – | 11.5 | 0.41 | 0.38 | IC1 | 18.75 | 1.48 | 1.33 | IC3 | + 0.6 | + 2 |
11 | pT1c, pN1a | 38% | 3 | +/− (69%/0%) | + | 6.25 | 0.35 | 0.22 | IC1 | 5 | 1.59 | 0.65 | IC2 | −0.2 | + 1 |
12 | pT2, N0 | 12% | 3 | +/+ (98%/100%) | + | 61.25 | 2.21 | 1.81 | IC1 | 72.5 | 3.52 | 1.99 | IC3 | + 0.2 | + 2 |
13 | pT2, pN0 | 87% | 3 | +/+ (100%/7%) | – | 31.25 | 1.69 | 0.06 | IC1 | 55 | 1.77 | 0.98 | IC3 | + 0.8 | + 2 |
14 | N/A | N/A | 1 | +/+ (100%/100%) | – | 1 | n/a | n/a | n/a | 1 | n/a | n/a | n/a | 0 | n/a |
15 | pT1c, N0 | 30% | 2 | +/+ (100%/50%) | – | 3.5 | 1.26 | n/a | IC0 | 7 | 1.14 | 0.76 | IC2 | + 1 | + 2 |
16 | pT1b, N0 | 95% | 3 | −/− (0%/0%) | – | 1 | 0.38 | 0.03 | IC0 | 13.75 | 0.99 | 0.06 | IC3 | + 12.8 | + 3 |