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Table 3 Adjusted association between BPE and breast cancer in the IMAGINE study

From: Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study

Premenopausal women

BPE classificationa

Cases

Controls

ORb

95% CI

4-level BPE

N (%)

N (%)

  

 Minimal

84 (18%)

107 (18%)

Reference

 

 Mild

206 (43%)

287 (48%)

1.00

0.63–1.58

 Moderate

138 (29%)

137 (23%)

1.72

1.03–2.88

 Marked

49 (10%)

62 (10%)

1.00

0.51–1.94

Dichotomous BPE

 Minimal/mild BPEc

290 (61%)

394 (66%)

Reference

 

 Moderate/marked BPE

187 (39%)

199 (34%)

1.49

1.05–2.11

Women with BMI < 25d

 Minimal/mild BPE

197 (65%)

266 (70%)

Reference

 

 Moderate/marked BPE

106 (35%)

112 (30%)

1.31

0.84–2.03

Women with BMI ≥ 25

 Minimal/mild BPE

93 (53%)

128 (60%)

Reference

 

 Moderate/marked BPE

81 (47%)

87 (40%)

1.86

1.03–3.37

Postmenopausal women

BPE classification

Cases

Controls

ORa

95% CI

 Minimal

94 (36%)

162 (50%)

Reference

 

 Mild

125 (48%)

124 (39%)

1.42

0.89–2.28

 Moderate

31 (12%)

30 (9%)

1.64

0.75–3.59

 Marked

10 (4%)

6 (2%)

1.32

0.38–4.55

Dichotomous BPE

 Minimal BPEc

94 (36%)

162 (50%)

Reference

 

 Mild/moderate/marked BPE

166 (64%)

160 (50%)

1.45

0.92–2.27

Women with BMI < 25

 Minimal BPE

56 (52%)

116 (57%)

Reference

 

 Mild/moderate/marked BPE

52 (48%)

86 (43%)

1.06

0.58–1.96

Women with BMI ≥ 25

 Minimal BPE

38 (25%)

46 (38%)

Reference

 

 Mild/moderate/marked BPE

114 (75%)

74 (62%)

2.20

1.02–4.71

  1. Abbreviations: OR odds ratio, CI confidence interval, BMI body mass index
  2. aEstimated for a single unaffected breast using BI-RADS (Breast Imaging - Reporting and Data System) guidelines by a single research radiologist blinded to case-control status, clinical characteristics, and medical history
  3. bORs are estimated in a multivariable conditional logistic regression model with adjustment for FGT (heterogeneous/dense vs fatty/scattered); history of simple hysterectomy; BMI (< 25, ≥ 25 and < 30, ≥ 30 kg/m¬2); parity; 1st-degree female family history or 1st- or 2nd-degree male family history of breast cancer; BRCA testing history; presence of BRCA mutations; history of lobular carcinoma in situ (LCIS); history of benign breast disease; and conditioned on matching criteria: race/ethnicity (non-Hispanic White vs other), recruitment site, and age at MRI (5-year categories)
  4. cParameterization of BPE differs for premenopausal and postmenopausal women to capture differing distributions of BPE in these groups
  5. dModels stratified by BMI at the time of MRI
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Breast Cancer Research

ISSN: 1465-542X

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