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Table 1 Characteristics of the IMAGINE study participants

From: Association of breast cancer with MRI background parenchymal enhancement: the IMAGINE case-control study

 

Premenopausal women

Postmenopausal women

Cases

Controls

Cases

Controls

N = 553

N = 623

N = 282

N = 340

Age, median (25th, 75th percentile)

45 (40, 48)

42 (37, 47)

59 (55, 63)

57 (53, 62)

Recruitment site

 Memorial Sloan Kettering Cancer Center

373 (67%)

431 (69%)

165 (59%)

223 (66%)

 University of Pennsylvania Medical Center

65 (12%)

67 (11%)

44 (16%)

50 (15%)

 University of Utah Huntsman Cancer Institute

115 (21%)

125 (20%)

73 (26%)

67 (20%)

Menopausal status and reasona

 Premenopausal

537 (97%)

597 (96%)

  

 Premenopausal (simple hysterectomy)

16 (3%)

26 (4%)

  

 Postmenopausal (natural)

  

212 (75%)

207 (61%)

 Postmenopausal (oophorectomy)

  

25 (9%)

93 (27%)

 Postmenopausal (simple hysterectomy)

  

38 (13%)

37 (11%)

 Postmenopausal (reason unknown)

  

7 (3%)

3 (1%)

Race/ethnicity

 Non-Hispanic White

451 (81%)

513 (82%)

227 (80%)

301 (89%)

 Non-Hispanic Black

31 (6%)

24 (4%)

17 (6%)

14 (4%)

 Non-Hispanic Asian

31 (6%)

26 (4%)

15 (5%)

10 (3%)

 Non-Hispanic (another race)

10 (2%)

16 (3%)

3 (1%)

3 (1%)

 Hispanic (any race)

30 (5%)

44 (7%)

20 (8%)

12 (3%)

Ever smoker

 Never

426 (77%)

485 (78%)

194 (69%)

254 (75%)

 Ever

127 (23%)

138 (22%)

88 (31%)

86 (25%)

Body mass index at time of MRIb (kg/m2)

 < 25

346 (63%)

400 (64%)

113 (40%)

208 (61%)

 25 to < 30

121 (22%)

143 (23%)

96 (34%)

67 (20%)

 ≥ 30

85 (15%)

78 (13%)

73 (26%)

64 (19%)

 Unknown

1

2

0

1

Parity

 0

194 (35%)

230 (37%)

67 (24%)

83 (24%)

 1

89 (15%)

77 (12%)

49 (17%)

50 (15%)

 2+

270 (50%)

316 (51%)

166 (59%)

197 (61%)

Family history of breast cancerc

 No

399 (77%)

210 (34%)

181 (68%)

103 (31%)

 Yes

116 (23%)

399 (66%)

85 (32%)

231 (69%)

 Unknown (n)

38

14

16

6

BRCA1 mutationd

 Negative

340 (66%)

202 (33%)

99 (36%)

127 (39%)

 Positive

9 (1.7%)

78 (13%)

4 (1.4%)

29 (8.8%)

 Not tested

166 (32%)

329 (54%)

173 (63%)

173 (53%)

 Unknown

38

14

6

11

BRCA2 mutationd

 Negative

340 (66%)

202 (33%)

95 (34%)

105 (32%)

 Positive

9 (1.7%)

78 (13%)

8 (2.9%)

51 (16%)

 Not tested

166 (32%)

329 (54%)

173 (63%)

173 (53%)

 Unknown

38

14

6

11

History of LCIS

 No

546 (99%)

584 (94%)

274 (97%)

302 (89%)

 Yes

7 (1%)

39 (6%)

8 (3%)

38 (11%)

History of benign breast disease

 No

443 (80%)

332 (53%)

210 (74%)

160 (47%)

 Yes

110 (20%)

291 (47%)

72 (26%)

180 (53%)

MRIfibroglandular tissue

 Almost entirely fat

    

 Scattered FGT

    

Characteristics of cases

N = 553

 

N = 282

 

Estrogen receptor

 Negative

88 (16%)

 

59 (21%)

 

 Positive

462 (84%)

 

222 (79%)

 

 Unknown

3

 

1

 

Progesterone receptor

 Negative

114 (21%)

 

91 (33%)

 

 Positive

436 (79%)

 

188 (67%)

 

 Unknown

3

 

3

 

HER2 expression

 Negative

443 (82%)

 

236 (86%)

 

 Positive

95 (18%)

 

37 (14%)

 

 Unknown

15

 

9

 

Triple-negativee subtype

 No

483 (90%)

 

232 (85%)

 

 Yes

55 (10%)

 

41 (15%)

 

 Unknown

15

 

9

 

Histology

 Ductal only

492 (90%)

 

226 (82%)

 

 Mixed ductal/lobular

6 (1%)

 

3 (1%)

 

 Lobular

43 (8%)

 

39 (14%)

 

 Other

5 (1%)

 

9 (3%)

 

 Unknown

7

 

5

 

Stage

 Localized (breast only)

383 (69%)

 

214 (76%)

 

 Regional (breast and regional nodes)

162 (29%)

 

62 (22%)

 

 Distant

8 (2%)

 

4 (2%)

 

 Unknown

0

 

2

 
  1. Abbreviation: LCIS lobular carcinoma in situ, HER2 human epidermal growth factor 2
  2. a“Premenopausal” refers to women who report continued menstrual cycles; “premenopausal (simple hysterectomy”) refers to women whose menstrual cycles stopped after a simple hysterectomy and were under 50 years of age at time of MRI; “postmenopausal” refers to women who reported a natural stop of menstrual cycles; “postmenopausal (oophorectomy)” refers to women who underwent menopause due to a bilateral oophorectomy; “postmenopausal (simple hysterectomy) refers to women whose menstrual cycles stopped after a hysterectomy and were 50 years of age or older at the time of MRI; “postmenopausal (other)” refers to women whose menstrual cycle stopped due to medication or medical procedures or did not give further details
  3. bCalculated using self-reported height (m) and weight (kg)
  4. cIncludes 1st-degree female relatives and any1st- or 2nd-degree male relative
  5. dSelf-reported by participants via structured questionnaire; variants of unknown significance were considered negative
  6. eTriple-negative refers to women with tumors negative for estrogen receptors, progesterone receptors, and HER2 expression
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Breast Cancer Research

ISSN: 1465-542X

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