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Table 1 EGFR-targeted and non-targeted antibody-drug conjugates

From: Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

ADC

Antibody

Linker

Payload

ABT-414

ABT-806

mc (non-cleavable)

MMAF

AB095-MMAF

AB095

mc (non-cleavable)

MMAF

ABBV-321

ABT-806 AM1

mc-VC (cleavable)

PBD

AB095-PBD

AB095

mc-VC (cleavable)

PBD