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Fig. 3 | Breast Cancer Research

Fig. 3

From: Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

Fig. 3

ABT-263/navitoclax enhances ABT-414 treatment responses within HCI-010 tumors. HCI-010 tumors were treated with vehicles, ABT-263, ABT-414, ABT-263+ABT-414, AB095-MMAF, or ABT-263+AB095-MMAF (Supplemental Figure 1b). Graphs present tumor growth as a percent of pre-treatment tumor volumes for each tumor (n = 5 per group). Each symbol represents a tumor. Each line represents the mean. Thirteen days post-treatment, significant tumor volume reductions and regressions were observed following either ABT-263 or ABT-263+ABT-414 treatments (a). Note greater regressions achieved after combined treatments. Note tumor growth was unaffected by ABT-414 or AB095-MMAF single agents. Note that ABT-263+AB095-MMAF was comparable to single-agent ABT-263. p values < 0.05 (*) are indicated for the most relevant comparisons (Welch’s one-tailed test: ABT-263 versus ABT-263+ABT-414 and ABT-263+ABT-414 versus ABT-263+AB095-MMAF). p values, determined by Welch’s one-tailed test, for vehicles versus ABT-263, ABT-414, ABT-263+ABT-414, AB095-MMAF, and ABT-263+AB095-MMAF, are presented in Supplemental Table 2b. Representative H&E images for tumors, corresponding to each treatment group, are shown (b) to highlight pathological responses associated with ABT-263 combined treatments. Scale bar, ~ 200 μm

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