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Fig. 4 | Breast Cancer Research

Fig. 4

From: Immune phenotype of patients with stage IV metastatic inflammatory breast cancer

Fig. 4

Analysis of PD-1 and PD-L1 expression in tumor biopsies from stage IV IBC patients. Sixteen tumor biopsy samples from 11 patients were stained by immunohistochemistry for PD-1 and PD-L1. Biopsies from patients #1, 5, and 8 were not available for evaluation. Details on biopsies are provided in Supplementary Table S3. a PD-1 and PD-L1 staining in brown is shown in samples from a representative patient. Magnification is × 600 in each image and bars designate 40 μm. b The expression scores for PD-1 and PD-L1 for tumor biopsy samples from the 11 patients assayed. Score definitions are provided in the “Methods” section. Values represent the maximum measured PD-1 or PD-L1 values in cases where a second measurement was made (all values shown in Supplementary Figure S3). Gray shaded patients had blood samples acquired within 1 month of tumor biopsies and were utilized for blood to tumor comparisons in Fig. 5. c Positive correlation between PD-L1 score (y-axis) and PD-1 score (x-axis) from the 11 patients evaluated using maximum values from panel b. Open squares designate overlapping datapoints from two patients. P and R values were computed from a Spearman test. The line is a least-squares fit to the data that is provided for visual purposes

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