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Table 4 Results of backward elimination and significance of FISH telomere values for each cognitive domain

From: Telomere lengths in women treated for breast cancer show associations with chemotherapy, pain symptoms, and cognitive domain measures: a longitudinal study

Domain

Remaining fixed effects after backwards elimination in model

Remaining random effects1

Coefficient for MMqPCR telomere values (p value)

Significantly associated chromosomes using chromosome-specific values (p value < 0.5)

Psychomotor speed

Time, stage, progesterone positive, surgery, age, race

1 + time

1.93 (0.40)

All

Reaction time

Time, time, estrogen positive, HER positive, neoadjuvant, chemo final

1 + time

1.22 (0.40)

All

Complex attention

Time, estrogen positive, HER positive, chemo final, education

1

0.19 (0.94)

None

Cognitive flexibility

Time, HER positive, chemo final, age, race

1

1.14 (0.54)

All

Executive functioning

Time, HER positive, chemo final, age, race

1

1.21 (0.51)

All

Memory

Surgery, depression

1 + time

− 2.45 (0.18)

All

Verbal memory

Race, BMI

1

1.90 (0.39)

All

Visual memory

Surgery, education, depression

1

− 1.22 (0.53)

All

  1. 1In the third column, “1” represents random intercept and “time” represents random slop