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Fig. 3 | Breast Cancer Research

Fig. 3

From: Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Fig. 3

Epithelial and mesenchymal marker analysis of the ED03 & EDW01 PDX tumours over serial passages (ED03 early: passage 3, mid: passage 7, late: passage 11; EDW01 early: passage 3, mid: passage 5, late: passage 7). Nuclei counterstained with haematoxylin. NEG: negative control (concentration and isotype matched IgG substituted for primary antibody) Arrows indicate Twist1-positive nuclei. 10× magnification, scale bar, 50 μm. Row 2 selected higher magnification areas: scale bar, 20 μm. H&E stained sections from a subset of donor blocks from which cores were derived can be found in Supplementary Fig. 2

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