Fig. 2From: Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model systemImmunohistochemical analysis (brown) of ED03 and EDW01 PDXs at various passages in mice for oestrogen receptor alpha (ERα) and progesterone receptor (PR). Nuclei counterstained with haematoxylin. a 4× magnification, scale bar, 200 μm. b 10× magnification, scale bar, 50 μM. c Plot of average % positivity per core for each PDX per passage number. ED03: p3; n = 2, p4; n = 4, p5; n = 4, p6; n = 2, p7; n = 4. EDW01: p3; n = 8, p4; n = 10, p4: n = 8, p5; n = 7, p6; n = 3, p7; n = 3. H&E stained sections from a subset of donor blocks from which cores were derived can be found in Supplementary Fig. 2Back to article page