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Fig. 2 | Breast Cancer Research

Fig. 2

From: Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Fig. 2

Immunohistochemical analysis (brown) of ED03 and EDW01 PDXs at various passages in mice for oestrogen receptor alpha (ERα) and progesterone receptor (PR). Nuclei counterstained with haematoxylin. a 4× magnification, scale bar, 200 μm. b 10× magnification, scale bar, 50 μM. c Plot of average % positivity per core for each PDX per passage number. ED03: p3; n = 2, p4; n = 4, p5; n = 4, p6; n = 2, p7; n = 4. EDW01: p3; n = 8, p4; n = 10, p4: n = 8, p5; n = 7, p6; n = 3, p7; n = 3. H&E stained sections from a subset of donor blocks from which cores were derived can be found in Supplementary Fig. 2

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