Univariable | Multivariablea | |||
---|---|---|---|---|
Variable | BCFi | OS | BCFi | OS |
HR (95% CI); P value | ||||
TILs, categoryb | ||||
All subtypes | (n = 221) | (n = 213) | ||
Low (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Intermediate | 1.10 (0.78–1.54); 0.61 | 1.26 (0.88–1.80); 0.21 | 0.61 (0.40–0.93); 0.02c | 0.65 (0.41–1.02); 0.06 |
High | 0.40 (0.22–0.71); 0.002 | 0.52 (0.29–0.95); 0.03 | 0.22 (0.11–0.43); < 0.001 | 0.23 (0.11–0.48); < 0.001 |
ER+/HER2− | (n = 136) | (n = 135) | ||
Low (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Intermediate | 1.02 (0.63–1.64); 0.94 | 1.02 (0.61–1.71); 0.95 | 0.69 (0.42–1.15); 0.16 | 0.65 (0.37–1.15); 0.14 |
High | 0.40 (0.14–1.09); 0.07 | 0.55 (0.20–1.52); 0.25 | 0.20 (0.06–0.60); 0.004 | 0.30 (0.10–0.96); 0.04 |
HER2+ | (n = 38) | (n = 35) | ||
Low (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Intermediate | 1.47 (0.62–3.49); 0.39 | 1.07 (0.45–2.56); 0.88 | 0.47 (0.14–1.60); 0.23 | 0.38 (0.11–1.31); 0.13 |
High | 0.28 (0.08–0.97); 0.05 | 0.27 (0.08–0.96); 0.04 | 0.06 (0.01–0.56); 0.01 | 0.05 (0.01–0.39); 0.005 |
TNBC | (n = 47) | (n = 43) | ||
Low (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Intermediate | 0.76 (0.31–1.87); 0.55 | 1.24 (0.49–3.14); 0.65 | 0.59 (0.21–1.67); 0.32 | 1.02 (0.34–3.11); 0.97 |
High | 0.27 (0.08–0.88); 0.03 | 0.44 (0.14–1.36); 0.16 | 0.38 (0.11–1.39); 0.15 | 0.59 (0.16–2.26); 0.44 |
Covariables | (n = 216–221) | (n = 213) | ||
Age (years) | ||||
< 40 (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
≥ 40 | 0.72 (0.49–1.04); 0.08 | 0.65 (0.44–0.96); 0.03 | 0.60 (0.40–0.89); 0.01 | 0.56 (0.37–0.85); 0.006 |
Nodal status | ||||
0 (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
1–3 | 1.31 (0.87–1.96); 0.19 | 1.59 (1.03–2.47); 0.04 | 1.21 (0.77–1.91); 0.40 | 1.69 (1.03–2.77); 0.04 |
≥ 4 | 2.33 (1.49–3.64); < 0.001 | 2.81 (1.75–4.52); < 0.001 | 2.03 (1.25–3.29); 0.004 | 2.70 (1.58–4.52); < 0.001 |
Tumour size (mm) | ||||
≤ 20 (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
> 20 | 1.04 (0.75–1.45); 0.80 | 0.92 (0.66–1.29); 0.63 | 1.23 (0.86–1.76); 0.25 | 1.04 (0.72–1.51); 0.84 |
Histological grade (NHG) | ||||
1 (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
2 | 1.51 (0.84–2.72); 0.17 | 1.34 (0.73–2.45); 0.35 | 1.36 (0.74–2.48); 0.32 | 1.13 (0.60–2.11); 0.71 |
3 | 1.82 (1.03–3.23); 0.04 | 1.96 (1.09–3.54); 0.03 | 2.70 (1.36–5.33); 0.004 | 2.25 (1.08–4.66); 0.03 |
ER | ||||
Negative (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Positive | 0.94 (0.66–1.34); 0.74 | 0.69 (0.49–0.99); 0.04 | 0.41 (0.12–1.36); 0.15 | 0.37 (0.11–1.27); 0.11 |
PR | ||||
Negative (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Positive | 1.06 (0.75–1.49); 0.75 | 0.80 (0.57–1.14); 0.21 | 2.38 (0.77–7.30); 0.13 | 1.76 (0.57–5.48); 0.33 |
HER2 | ||||
Negative (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Positive | 1.10 (0.72–1.69); 0.65 | 1.26 (0.81–1.94); 0.30 | 1.05 (0.66–1.67); 0.85 | 1.11 (0.68–1.82); 0.67 |
LVI | ||||
Absent (Ref.) | 1.00 | 1.00 | 1.00 | 1.00 |
Present | 1.49 (1.08–2.05); 0.02 | 1.26 (0.90–1.76); 0.18 | 1.39 (0.99–1.95); 0.06 | 1.05 (0.73–1.51); 0.78 |