Table 1 Distribution of TILs according to patient and tumour characteristics (n = 477)
Variable | TIL low (< 10%) n (%) | TIL intermediate (10–49%) n (%) | TIL high (≥ 50%) n (%) | P valuea |
|---|---|---|---|---|
Age (years) | 0.02 | |||
< 40 | 41 (44) | 32 (34) | 21 (22) | |
≥ 40 | 207 (54) | 125 (33) | 51 (13) | |
Nodal status | 0.34 | |||
0 | 65 (47) | 42 (31) | 30 (22) | |
1–3 | 137 (59) | 66 (28) | 30 (13) | |
≥ 4 | 46 (44) | 47 (45) | 12 (11) | |
Missing | 0 | 2 | 0 | |
Tumour size (mm) | 0.06 | |||
≤ 20 | 97 (57) | 52 (31) | 20 (12) | |
> 20 | 151 (49) | 104 (34) | 52 (17) | |
Missing | 0 | 1 | 0 | |
Histological grade (NHG) | < 0.001 | |||
1 | 44 (86) | 7 (14) | 0 | |
2 | 135 (70) | 52 (27) | 5 (3) | |
3 | 56 (27) | 91 (43) | 64 (30) | |
Missing | 13 | 7 | 3 | |
ER | < 0.001 | |||
Negative | 45 (29) | 63 (40) | 48 (31) | |
Positive | 203 (63) | 94 (29) | 24 (8) | |
PR | < 0.001 | |||
Negative | 41 (27) | 63 (41) | 50 (33) | |
Positive | 206 (64) | 93 (29) | 21 (7) | |
Missing | 1 | 1 | 1 | |
HER2 | 0.001 | |||
Negative | 205 (56) | 109 (30) | 50 (14) | |
Positive | 22 (33) | 28 (42) | 16 (24) | |
Missing | 21 | 20 | 6 | |
LVI | 0.87 | |||
Absent | 140 (54) | 76 (30) | 42 (16) | |
Present | 108 (50) | 81 (37) | 28 (13) | |
Missing | 0 | 0 | 2 | |
Ki67 (%) | < 0.001 | |||
≤ 10 | 126 (71) | 40 (23) | 12 (7) | |
11–25 | 60 (56) | 33 (31) | 14 (13) | |
≥ 26 | 22 (20) | 53 (48) | 36 (32) | |
Missing | 40 | 31 | 10 | |
Histopathological type | < 0.001 | |||
Ductal/NST | 200 (52) | 134 (35) | 48 (13) | |
Lobular | 29 (81) | 7 (19) | 0 | |
Medullary | 0 | 3 (13) | 20 (87) | |
Other | 9 (75) | 2 (17) | 1 (8) | |
Missing | 10 | 11 | 3 | |
Subtype | < 0.001 | |||
ER+/HER2− | 176 (69) | 65 (25) | 16 (6) | |
HER2+ | 22 (33) | 28 (42) | 16 (24) | |
TNBC | 20 (21) | 42 (44) | 33 (35) | |
Missing | 30 | 22 | 7 | |
Total | 248 (52) | 157 (33) | 72 (15) | |