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Fig. 5 | Breast Cancer Research

Fig. 5

From: Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Fig. 5

FAK pathway inhibition attenuates increased invasion after EV treatment. Invasion assays were performed and analyzed as described above treating MCF10DCIS.com cells with EVs isolated from MDA.MB231 cells in the presence and absence of a FAK inhibitor (PF.573.228). a Incubation with FAK inhibitor decreases phosphorylated FAK protein as detected by flow cytometry. b Representative images of cell densities (yellow) overlaid with initial scratch wounds (purple). c The average percent invasion of 4 replicate wells containing MCF10DCIS.com cells treated with EVs ± 3 μM FAK inhibitor

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