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Fig. 4 | Breast Cancer Research

Fig. 4

From: Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach

Fig. 4

EVs alter expression of genes in the FAK pathway in treated MCF10DCIS.com breast cancer cells. MCF10DCIS.com cells were incubated with EVs from YWBC patients, healthy donors (HD), or MDA231 breast cancer cells for 18 h prior to RNA isolation. Gene expression related to cancer pathways and cancer progression was measured using NanoString technology. Data were normalized and statistical analysis performed using the NanoString nSolver3.0 analysis software. Heatmap of the top 8 genes related to the FAK pathway comparing MCF10DCIS.com cells treated with EVs from YWBC patients to HD (left) or from invasive MDA231 breast cancer cells to untreated controls (right), *p < 0.05

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Breast Cancer Research

ISSN: 1465-542X

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