TY - JOUR AU - Jordan, Kimberly R. AU - Hall, Jessica K. AU - Schedin, Troy AU - Borakove, Michelle AU - Xian, Jenny J. AU - Dzieciatkowska, Monika AU - Lyons, Traci R. AU - Schedin, Pepper AU - Hansen, Kirk C. AU - Borges, Virginia F. PY - 2020 DA - 2020/11/23 TI - Extracellular vesicles from young women’s breast cancer patients drive increased invasion of non-malignant cells via the Focal Adhesion Kinase pathway: a proteomic approach JO - Breast Cancer Research SP - 128 VL - 22 IS - 1 AB - Extracellular vesicles (EVs) are small membrane particles that contribute to cancer progression and metastases by transporting biologically significant proteins and nucleic acids. They may also serve as biomarkers of various disease states or important therapeutic targets. Breast cancer EVs have the potential to change the behavior of other cells in their microenvironment. However, the proteomic content of EVs isolated from young women’s breast cancer patients and the mechanisms underlying the influence of EVs on tumor cell behavior have not yet been reported. SN - 1465-542X UR - https://doi.org/10.1186/s13058-020-01363-x DO - 10.1186/s13058-020-01363-x ID - Jordan2020 ER -