Fig. 3

Overall efficacy data. a Kaplan-Meier curves (PFS) for the whole population (left) and split by hormonal subtype (TNBC, 2.6 months; hormone-positive, 3.3 months; log-rank P value, 0.84). b Kaplan-Meier curves (OS) for the whole population (left) and split by subtype (TNBC, 7.4 months; hormone-positive, 19.8 months; log-rank P value, 0.11). c Waterfall plot showing best percentage change from baseline in the sum of the longest diameters of target lesions. This plot depicts the changes among the N = 21 patients with measurable disease; the remaining patients (N = 4) had bone disease only (non-measurable but evaluable disease, according to RECIST 1.1). The patient that was non-evaluated due to clinical PD was one of the patients with non-measurable disease. d Swimmer plot depicting the time and durability of response of the 25 patients included in the trial. e Spider plot displaying the longitudinal change from baseline in the sum of the longest diameters of target lesions. It depicts the changes among the same N = 21 patients as in (c). Patients in (c), (d), and (e) are labeled according to their hormonal status: red dot, hormone-positive; black dot, TNBC