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Table 1 Pathways that are differentially regulated in MCF7 versus TAMR and in TAMR after ATF2 silencing. Commonly identified pathways dysregulated between MCF7 and TAMRs and re-instated after ATF2 knockdown. The complete list of KEGG and REACTOME pathways are presented in Supplementary files 1 (MCF7 vs TAMR) and 2 (TAMRs after siATF2 knockout)

From: Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer

Number term ID

Term description

Pathways upregulated in MCF7 (downregulated in TAMRs)

 HSA-9018519

Oestrogen-dependent gene expression

 HSA-9006931

Signalling by Nuclear Receptors

Pathways upregulated in TAMRs after siATF2

 HSA-9018519

Oestrogen-dependent gene expression

 HSA-9006931

Signalling by Nuclear Receptors

Pathways downregulated in MCF7 (upregulated in TAMRs)

 hsa03010

Ribosome

 HSA-8953854

Metabolism of RNA

 HSA-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

 HSA-1799339

SRP-dependent cotranslational protein targeting to membrane

 HSA-71291

Metabolism of amino acids and derivatives

Pathways downregulated in TAMRs after siATF2

 hsa03010

Ribosome

 HSA-8953854

Metabolism of RNA

 HSA-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

 HSA-1799339

SRP-dependent cotranslational protein targeting to membrane

 HSA-71291

Metabolism of amino acids and derivatives