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Fig. 4 | Breast Cancer Research

Fig. 4

From: Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer

Fig. 4

Differential gene expression analysis after ATF2 silencing revealed ER-responsive genes and pathways regulated by ATF2 in TAMR. Heatmaps of genes that were a upregulated and b downregulated in TAMRs (red) cells after ATF2 silencing relative to MCF7 (blue). c Enrichment analysis revealed ATF2 silencing in TAMR cells leads to the reintroduction of the ER signalling network and a reduction in MYC. Venn diagrams of differentially regulated genes in TAMRs after ATF2 silencing. A total of 543 upregulated (d) and 483 downregulated (e) genes were commonly identified after both ATF2-siRNA knockdown (si1 and si2 vs siNT)

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Breast Cancer Research

ISSN: 1465-542X

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