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Fig. 3 | Breast Cancer Research

Fig. 3

From: Activating transcription factor-2 (ATF2) is a key determinant of resistance to endocrine treatment in an in vitro model of breast cancer

Fig. 3

Differential gene expression analysis in basal MCF7 versus TAMR cell lines revealed an ATF2-enriched transcription factor network. a Heatmap of genes that were differentially expressed in MCF7 (blue) relative to TAMR (red) cells at basal level. This analysis identified 3260 upregulated and 4423 downregulated genes in TAMR cells relative to MCF7. b Enrichment analysis identified a shift from the ER (ESR1)-enriched transcription factor network present on MCF7 (blue) towards an ATF2-enriched transcription factor network on TAMR (red). c KEGG enrichment also identified a shift from the oestrogen and progesterone pathways to TGF-β and metabolic pathways

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Breast Cancer Research

ISSN: 1465-542X

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