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Table 3 BMI and hormone receptor status as predictive factors of pCR

From: Effect of body mass index on response to neo-adjuvant therapy in HER2-positive breast cancer: an exploratory analysis of the NeoALTTO trial

   

Univariate analysis

Multivariate analysis°

BMI categories

N

pCR (%)

OR (95%CI)

p value

OR (95%CI)

p value

HR-positive population

231

62 (26.8)

    

 Underweight/normal

121

39 (32.2)

1

 

1

 

 Overweight/obese

110

23 (20.9)

0.56 (0.31–1.01)

0.054

0.55 (0.30–1.01)

0.053

HR-negative population

223

98 (43.9)

    

 Underweight/normal

113

46 (40.7)

1

0.324

1

0.331

 Overweight/obese

110

52 (47.3)

1.31 (0.77–2.22)

 

1.30 (0.76–2.23)

 
   

p value HR+ vs HR−

< 0.0001

  
   

p value for interaction

0.036

  
  1. BMI body mass index, pCR pathological complete response, HR hormone receptor, OR odds ratio, CI confidence interval
  2. °Adjusted for planned surgery, nodal status, and tumor size