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Fig. 5 | Breast Cancer Research

Fig. 5

From: A tumour suppressive relationship between mineralocorticoid and retinoic acid receptors activates a transcriptional program consistent with a reverse Warburg effect in breast cancer

Fig. 5

Effect of MR and RAR signalling on breast cancer cell proliferation. The meta-PCNA genes which are the top 1% of genes most highly correlated with the proliferating cell nuclear antigen (PCNA), a well-known proliferation marker is used to calculate the meta-PCNA index which is defined as the median expression of meta-PCNA genes. a PCNA index as a proliferation measure for MR-inducible cells under different treatment conditions. Here, Dox is used to induce MR; therefore, Dox alone is equivalent to vehicle treatment of MR containing cells. P values are based on paired Wilcoxon signed-rank test of the expression of meta-PCNA genes for each treatment comparison of interest. b Expression of meta-PCNA genes under different treatment conditions of MR-inducible MCF-7 breast cancer cells

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Breast Cancer Research

ISSN: 1465-542X

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