Skip to main content

Table 1 Baseline characteristics

From: Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer

Characteristic

No. of patients (%)

Age, years

 Median (range)

53 (29–79)

Sex

 Female

50 (100)

 Male

0 (0)

Race

 White

46 (92)

 Black

1 (2)

 Asian

1 (2)

 Other

2 (4)

Ethnicity

 Hispanic or Latino

12 (24)

 Non-Hispanic

37 (74)

 Unknown

1 (2)

ECOG PS at baseline

 0

32 (64)

 1

18 (36)

Disease-free interval (from primary diagnosis to metastatic diagnosis)

 De novo metastatic disease

5 (10)

 ≤ 2 years

25 (50)

 > 2 years

20 (40)

Sites of disease at inclusion

 CNS

2 (4)

 Lung or pleural effusion

13 (26)

 Liver

5 (10)

 Bone

8 (16)

 Breast or chest wall

15 (30)

 Lymph nodes

20 (40)

 Soft tissue

2 (4)

 Other

4 (8)

Previous treatment

 Adjuvant or neoadjuvant chemotherapy

44 (88)

 Adjuvant or neoadjuvant anthracycline

36 (72)

 Adjuvant or neoadjuvant taxane

42 (84)

Lines of chemotherapy for metastatic or recurrent disease

 Median (range)

1.5 (0–7)

 None

7 (14)

 1 line

18 (36)

 2 lines

9 (18)

 3 or more lines

16 (32)

Prior metastatic chemotherapy

 Anthracycline

4 (8)

 Taxane

14 (28)

 Platinum

18 (36)

 Capecitabine

23 (46)

 Eribulin

8 (16)

 Other

26 (52)

  1. CNS central nervous system, ECOG PS Eastern Cooperative Oncology Group Performance Status