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Table 2 Breast cancer relative risk by biomarker level, New York Site of BCFR

From: Circulating growth factor concentrations and breast cancer risk: a nested case-control study of IGF-1, IGFBP-3, and breast cancer in a family-based cohort

  Breast cancer relative risk
  ORa (95% CI) ORb (95% CI)
IGF-1
 Log-transformed continuous IGF-1 (N = 236)
  1.19 (0.52, 2.70) 0.77 (0.26, 2.31)
 Median IGF-1 in controls (N = 236)
 < 93.95 ng/mL Reference Reference
 Elevated (≥ 93.95 ng/mL) 1.46 (0.80, 2.71) 1.37 (0.66, 2.85)
  ORa (95% CI) ORc (95% CI)
 Interaction with BOADICEA risk score (N = 231)
 Low IGF-1 (< 93.95), low BOADICEA risk (< 3.4%) (N = 27) Reference Reference
 Elevated IGF-1 (≥ 93.95), low BOADICEA risk (< 3.4%) (N = 48) 2.49 (0.72, 8.63) 2.76 (0.64, 11.9)
 Low IGF-1 (< 93.95), high BOADICEA risk (≥ 3.4%) (N = 81) 3.23 (0.99, 10.59) 3.74 (0.99, 14.2)
 Elevated IGF-1 (≥ 93.95), high BOADICEA risk (≥ 3.4%) (N = 75) 3.82 (1.20, 12.15)* 3.92 (1.07, 14.4)*
 RERI − 0.90 (− 4.22, 2.41) − 1.55 (− 5.80, 2.69)
p value for interaction 0.28 0.21
  ORa (95% CI) ORb (95% CI)
IGFBP-3
 Log-transformed continuous IGFBP-3 (N = 236)
  2.76 (0.84, 9.07) 4.90 (0.99, 24.1)
 Median IGFBP-3 in controls (N = 236)
 < 2009 Reference Reference
 Elevated (≥ 2009) 1.41 (0.79, 2.51) 1.62 (0.81, 3.24)
  ORa (95% CI) ORc (95% CI)
 Interaction with BOADICEA risk score (N = 231)
 Low IGFBP-3 (< 2009), low BOADICEA risk (< 3.4%) (N = 28) Reference Reference
 Elevated IGFBP-3 (≥ 2009), low BOADICEA risk (< 3.4%) (N = 47) 1.52 (0.48, 4.83) 2.08 (0.55, 7.92)
 Low IGFBP-3 (< 2009), high BOADICEA risk (≥ 3.4%) (N = 81) 2.09 (0.71, 6.13) 2.26 (0.70, 7.25)
 Elevated IGFBP-3 (≥ 2009), high BOADICEA risk (≥ 3.4%) (N = 75) 3.24 (1.09, 9.63)* 3.47 (1.04, 11.6)*
 RERI 0.63 (− 1.50, 2.77) 0.13 (− 2.60, 2.86)
p value for interaction 0.97 0.68
  1. Abbreviations: BCFR Breast Cancer Family Registry, CI confidence interval, IGF-1 insulin-like growth factor 1, IGFBP-3 insulin-like growth factor binding protein 3, RERI relative excess risk due to interaction
  2. aConditional logistic regression, unadjusted
  3. bConditional logistic regression, adjusted for age at blood draw, BMI, smoking status, alcohol consumption, menopausal status, continuous BOADICEA score, and opposing biomarker (IGF-1 or IGFBP-3)
  4. cConditional logistic regression, adjusted for age at blood draw, BMI, smoking status, alcohol consumption, menopausal status, and opposing biomarker (IGF-1 or IGFBP-3)
  5. *Statistically significant