Model 0a | Model 1b | Model 2c | |||||||
---|---|---|---|---|---|---|---|---|---|
Cases | Events | CYP27A1 high vs low HR (95%CI) | Cases | Events | CYP27A1 high vs low HR (95%CI) | Cases | Events | CYP27A1 high vs low HR (95%CI) | |
Follow-up period ≤ 5 years | |||||||||
Overall survival | |||||||||
All | 645 | 76 | 0.97 (0.56–1.69) | 569 | 69 | 0.86 (0.47–1.57) | 514 | 63 | 0.68 (0.35–1.31) |
P = 0.92 | P = 0.63 | P = 0.25 | |||||||
ER+ | 522 | 52 | 1.05 (0.53–1.03) | 498 | 51 | 1.09 (0.54–2.19) | 448 | 47 | 0.91 (0.43–1.93) |
P = 0.87 | P = 0.81 | P = 0.81 | |||||||
ER+ and age ≥ 55 yrs | 472 | 51 | 1.10 (0.55–2.21) | 450 | 50 | 1.11 (0.55–2.23) | 400 | 46 | 0.97 (0.46–2.05) |
P = 0.78 | P = 0.76 | P = 0.93 | |||||||
Breast cancer-specific survival | |||||||||
All | 645 | 46 | 0.92 (0.44–1.93) | 569 | 41 | 0.67 (0.30–1.51) | 514 | 38 | 0.54 (0.22–1.31) |
P = 0.83 | P = 0.34 | P = 0.17 | |||||||
ER+ | 522 | 26 | 0.61 (0.18–2.03) | 498 | 26 | 0.63 (0.19–2.10) | 448 | 25 | 0.57 (0.16–1.95) |
P = 0.42 | P = 0.45 | P = 0.37 | |||||||
ER+ and age ≥ 55 yrs | 472 | 25 | 0.64 (0.19–2.16) | 450 | 25 | 0.64 (0.19–2.14) | 400 | 24 | 0.63 (0.18–2.15) |
P = 0.47 | P = 0.47 | P = 0.46 | |||||||
Follow-up period > 5 years | |||||||||
Overall survival | |||||||||
All | 567 | 145 | 1.66 (1.14–2.43) | 498 | 129 | 1.89 (1.25–2.85) | 449 | 123 | 1.93 (1.26–2.97) |
P = 0.009 | P = 0.003 | P = 0.003 | |||||||
ER+ | 468 | 122 | 1.76 (1.14–2.71) | 445 | 117 | 1.79 (1.16–2.77) | 399 | 112 | 1.78 (1.13–2.80) |
P = 0.01 | P = 0.009 | P = 0.01 | |||||||
ER+ and age ≥ 55 yrs | 419 | 112 | 1.85 (1.18–2.91) | 398 | 107 | 1.91 (1.22–3.03) | 352 | 102 | 1.99 (1.24–3.21) |
P = 0.007 | P = 0.005 | P = 0.004 | |||||||
Breast cancer-specific survival | |||||||||
All | 567 | 66 | 2.18 (1.28–3.73) | 498 | 60 | 2.25 (1.26–4.01) | 449 | 58 | 2.33 (1.28–4.23) |
P = 0.004 | P = 0.006 | P = 0.006 | |||||||
ER+ | 468 | 54 | 2.22 (1.19–4.12) | 445 | 54 | 2.18 (1.18–4.03) | 399 | 52 | 2.26 (1.20–4.27) |
P = 0.01 | P = 0.01 | P = 0.01 | |||||||
ER+ and age ≥ 55 yrs | 419 | 46 | 2.56 (1.33–4.91) | 398 | 46 | 2.57 (1.34–4.94) | 352 | 44 | 2.78 (1.41–5.51) |
P = 0.005 | P = 0.005 | P = 0.003 |