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Table 1 Clinico-pathological characteristics of the study population

From: Inter-tumor genomic heterogeneity of breast cancers: comprehensive genomic profile of primary early breast cancers and relapses

Clinico-pathological features

Primary tumors (n = 133*)

N (%)

Subtype

IBC, NOS

114 (85.7%)

 

Lobular

7 (5.3%)

 

Other special types

7 (5.3%)

 

Mixed

5 (3.8%)

Molecular subtype (IHC surrogates)

Luminal B HER2−

68 (51.1%)

 

Luminal B HER2+

6 (4.5%)

 

HER2+ non-luminal

1 (0.8%)

 

Triple negative

58 (43.6%)

pT

1b

9 (6.7%)

 

1c

43 (32.3%)

 

2

55 (41.4%)

 

3

17 (12.8%)

 

4

4 (3%)

 

NA

5 (3.8%)

pN

0

34 (25.6%)

 

1–3

80 (60.2%)

 

NA

19 (14.3%)

Recurrences/metastasis (n = 135**)

N (%)

Site

Local (n = 47)

Axillary lymph node

24 (51.1%)

 

Skin

14 (29.8%)

 

Soft tissue

9 (19.1%)

Distant (n = 88)

Bone

2 (2.3%)

 

Liver

22 (25%)

 

Lung

14 (15.9%)

 

Lymph node

4 (4.5%)

 

Ovary

2 (2.3%)

 

Pleura

37 (42%)

 

Skin

3 (3.4%)

 

Soft tissue

4 (4.5%)

  1. The study populations included 128 women affected by breast cancer and relapsed in a timeframe of 17 years
  2. IHC immunohistochemistry, pT pathologic stage classification of primary tumor, pN pathologic stage classification of regional lymph nodes, IBC invasive breast carcinoma, NA not available
  3. *N = 133, 5 patients had multiple primary tumors
  4. **N = 135, 6 patients had multiple recurrences