Fig. 2
From: Fibroblasts direct differentiation of human breast epithelial progenitors
iHBFCs resemble HBFCs by gene expression profiles and CD140b and CD248 are lobular markers in situ. a Venn diagram showing the number of differentially expressed genes (DEGs; p < 0.05 and fold change ≥ 2) based on genome wide RNA-sequencing of CD105+ and CD26+ HBFCs and iHBFCs, respectively. Bar diagram shows the percent overlap of DEGs between the cells indicated. b Heatmap of expression values of DEGs annotated with a cluster of differentiation (CD) name represented in a for iHBFCCD105and iHBFCCD26. c Cryostat sections of normal breast biopsies stained with peroxidase (brown) for CD140b and CD248 selected based on the CD gene expression profile of iHBFCs. Note the relatively intense staining in TDLUs (left) versus ducts (right). Nuclei are counterstained with hematoxylin (blue) (bar = 100 μm)