Characteristics at the end of follow-up1 | All women (n = 62,512) | NSAID exposure at the end of follow-up | |
---|---|---|---|
Never/occasional users (n = 24,019) | Recurrent users (n = 38,493) | ||
Sociodemographic factors | |||
Age (years), mean (SD) | 72.1 (6.7) | 71.8 (6.7) | 72.2 (6.2) |
Educational level, N (%) | |||
< High school | 6516 (10) | 2160 (9) | 4356 (11) |
From high school to 4 years higher education | 45,138 (72) | 17,450 (73) | 27,688 (72) |
At least 5 years higher education | 10,858 (18) | 4409 (18) | 6449 (17) |
Lifestyle factors, N (%) | |||
BMI (kg/m2) | |||
< 18.5 | 2626 (4) | 1284 (5) | 1342 (3) |
[18.5–23[ | 25,409 (41) | 10,913 (45) | 14,496 (38) |
[23–25[ | 13,197 (21) | 5020 (21) | 8177 (21) |
[25–30[ | 16,139 (26) | 5359 (22) | 10,780 (28) |
≥ 30 | 5141 (8) | 1443 (6) | 3698 (10) |
Physical activity (Met-h/week) | |||
≤ 34.8 | 15,649 (25) | 5863 (24) | 9786 (25) |
]34.8–57.6] | 15,680 (25) | 5986 (25) | 9694 (25) |
]57.6–88.8] | 15,567 (25) | 6085 (25) | 9482 (25) |
> 88.8 | 15,616 (25) | 6085 (25) | 9531 (25) |
Smoking status | |||
Never smoker | 33,281 (53) | 13,258 (55) | 20,023 (52) |
Current smoker | 4741 (8) | 1681 (7) | 3060 (8) |
Past smoker | 24,490 (39) | 9080 (38) | 15,410 (40) |
Alcohol intake (g/day) | |||
Abstainer | 7832 (13) | 3283 (14) | 4549 (12) |
≤ 5 | 16,796 (27) | 6611 (28) | 10,185 (26) |
]5–10] | 9357 (15) | 3752 (16) | 5605 (15) |
]10–20] | 12,053 (19) | 4546 (19) | 7507 (20) |
> 20 | 12,522 (20) | 4483 (19) | 8039 (21) |
Missing | 3952 (6) | 1344 (6) | 2608 (7) |
Reproductive factors | |||
Breastfeeding, N (%) | |||
Never | 23,425 (37) | 9088 (38) | 14,337 (37) |
Ever | 34,174 (55) | 13,248 (55) | 20,926 (54) |
Missing | 4913 (8) | 1683 (7) | 3230 (9) |
Age at menopause (years), mean (SD) | 50.52 (3.73) | 50.68 (3.68) | 50.41 (3.76) |
Age at menarche (years), N (%) | |||
< 13 | 28,078 (45) | 10,413 (43) | 17,665 (46) |
≥ 13 | 34,434 (55) | 13,606 (57) | 20,828 (54) |
Parity and age at first full-term pregnancy, N (%) | |||
Nulliparous | 7282 (12) | 3010 (13) | 4272 (11) |
First child before age 30 years, one or two children | 31,393 (50) | 11,739 (49) | 19,654 (51) |
First child before age 30 years, three or more children | 17,373 (28) | 6602 (27) | 10,771 (28) |
First child after age 30 years | 6464 (10) | 2668 (11) | 3796 (10) |
Ever use of oral contraceptives, N (%) | 38,570 (62) | 14,191 (59) | 24,379 (63) |
Lifetime MHT use, N (%) | |||
Never | 17,273 (28) | 8076 (34) | 9197 (24) |
Recent | 5300 (8) | 1866 (8) | 3434 (9) |
Past | 39,939 (64) | 14,077 (59) | 25,862 (67) |
Medical events and medical follow-up, N (%) | |||
Number of medical consultations/visits during the preceding 6 months | |||
0 | 3277 (5) | 1928 (8) | 1349 (4) |
[1–4[ | 25,413 (41) | 11,387 (47) | 14,026 (36) |
≥ 4 | 33,491 (54) | 10,434 (43) | 23,057 (60) |
Missing | 331 (1) | 270 (1) | 61 (0) |
Self-report of a mammogram performed during the previous follow-up cycle | 51,097 (82) | 19,194 (80) | 31,903 (83) |
Personal history of benign breast disease | 23,268 (37) | 8483 (35) | 14,785 (38) |
History of breast cancer in first-degree relatives | 7139 (11) | 2735 (11) | 4404 (11) |
Recurrent use2 of other drugs, N (%) | |||
Systemic glucocorticoids | 17,391 (28) | 3551 (15) | 13,840 (36) |
Paracetamol | 38,392 (61) | 10,527 (44) | 27,865 (72) |
Proton pump inhibitors | 30,063 (48) | 6308 (26) | 23,755 (62) |
Anti-arthritics | 26,400 (42) | 6471 (27) | 19,929 (52) |
Comorbidities, N (%) | |||
History of arthrosis | 21,475 (34) | 5568 (23) | 15,907 (41) |
History of rheumatism | 6111 (10) | 2400 (10) | 3711 (10) |
History of arthritis | 888 (1) | 248 (1) | 640 (2) |
History of polyarthritis | 2375 (4) | 451 (2) | 1924 (5) |
History of spondyloarthritis | 236 (1) | 29 (1) | 207 (1) |
History of migraine | 21,591 (35) | 7073 (29) | 14,518 (38) |