|
Sociodemographic factors
|
|
Age (years), mean (SD)
|
72.1 (6.7)
|
71.8 (6.7)
|
72.2 (6.2)
|
|
Educational level, N (%)
|
|
< High school
|
6516 (10)
|
2160 (9)
|
4356 (11)
|
|
From high school to 4 years higher education
|
45,138 (72)
|
17,450 (73)
|
27,688 (72)
|
|
At least 5 years higher education
|
10,858 (18)
|
4409 (18)
|
6449 (17)
|
|
Lifestyle factors, N (%)
|
|
BMI (kg/m2)
|
|
< 18.5
|
2626 (4)
|
1284 (5)
|
1342 (3)
|
|
[18.5–23[
|
25,409 (41)
|
10,913 (45)
|
14,496 (38)
|
|
[23–25[
|
13,197 (21)
|
5020 (21)
|
8177 (21)
|
|
[25–30[
|
16,139 (26)
|
5359 (22)
|
10,780 (28)
|
|
≥ 30
|
5141 (8)
|
1443 (6)
|
3698 (10)
|
|
Physical activity (Met-h/week)
|
|
≤ 34.8
|
15,649 (25)
|
5863 (24)
|
9786 (25)
|
|
]34.8–57.6]
|
15,680 (25)
|
5986 (25)
|
9694 (25)
|
|
]57.6–88.8]
|
15,567 (25)
|
6085 (25)
|
9482 (25)
|
|
> 88.8
|
15,616 (25)
|
6085 (25)
|
9531 (25)
|
|
Smoking status
|
|
Never smoker
|
33,281 (53)
|
13,258 (55)
|
20,023 (52)
|
|
Current smoker
|
4741 (8)
|
1681 (7)
|
3060 (8)
|
|
Past smoker
|
24,490 (39)
|
9080 (38)
|
15,410 (40)
|
|
Alcohol intake (g/day)
|
|
Abstainer
|
7832 (13)
|
3283 (14)
|
4549 (12)
|
|
≤ 5
|
16,796 (27)
|
6611 (28)
|
10,185 (26)
|
|
]5–10]
|
9357 (15)
|
3752 (16)
|
5605 (15)
|
|
]10–20]
|
12,053 (19)
|
4546 (19)
|
7507 (20)
|
|
> 20
|
12,522 (20)
|
4483 (19)
|
8039 (21)
|
|
Missing
|
3952 (6)
|
1344 (6)
|
2608 (7)
|
|
Reproductive factors
|
|
Breastfeeding, N (%)
|
|
Never
|
23,425 (37)
|
9088 (38)
|
14,337 (37)
|
|
Ever
|
34,174 (55)
|
13,248 (55)
|
20,926 (54)
|
|
Missing
|
4913 (8)
|
1683 (7)
|
3230 (9)
|
|
Age at menopause (years), mean (SD)
|
50.52 (3.73)
|
50.68 (3.68)
|
50.41 (3.76)
|
|
Age at menarche (years), N (%)
|
|
< 13
|
28,078 (45)
|
10,413 (43)
|
17,665 (46)
|
|
≥ 13
|
34,434 (55)
|
13,606 (57)
|
20,828 (54)
|
|
Parity and age at first full-term pregnancy, N (%)
|
|
Nulliparous
|
7282 (12)
|
3010 (13)
|
4272 (11)
|
|
First child before age 30 years, one or two children
|
31,393 (50)
|
11,739 (49)
|
19,654 (51)
|
|
First child before age 30 years, three or more children
|
17,373 (28)
|
6602 (27)
|
10,771 (28)
|
|
First child after age 30 years
|
6464 (10)
|
2668 (11)
|
3796 (10)
|
|
Ever use of oral contraceptives, N (%)
|
38,570 (62)
|
14,191 (59)
|
24,379 (63)
|
|
Lifetime MHT use, N (%)
|
|
Never
|
17,273 (28)
|
8076 (34)
|
9197 (24)
|
|
Recent
|
5300 (8)
|
1866 (8)
|
3434 (9)
|
|
Past
|
39,939 (64)
|
14,077 (59)
|
25,862 (67)
|
|
Medical events and medical follow-up, N (%)
|
|
Number of medical consultations/visits during the preceding 6 months
|
|
0
|
3277 (5)
|
1928 (8)
|
1349 (4)
|
|
[1–4[
|
25,413 (41)
|
11,387 (47)
|
14,026 (36)
|
|
≥ 4
|
33,491 (54)
|
10,434 (43)
|
23,057 (60)
|
|
Missing
|
331 (1)
|
270 (1)
|
61 (0)
|
|
Self-report of a mammogram performed during the previous follow-up cycle
|
51,097 (82)
|
19,194 (80)
|
31,903 (83)
|
|
Personal history of benign breast disease
|
23,268 (37)
|
8483 (35)
|
14,785 (38)
|
|
History of breast cancer in first-degree relatives
|
7139 (11)
|
2735 (11)
|
4404 (11)
|
|
Recurrent use2 of other drugs, N (%)
|
|
Systemic glucocorticoids
|
17,391 (28)
|
3551 (15)
|
13,840 (36)
|
|
Paracetamol
|
38,392 (61)
|
10,527 (44)
|
27,865 (72)
|
|
Proton pump inhibitors
|
30,063 (48)
|
6308 (26)
|
23,755 (62)
|
|
Anti-arthritics
|
26,400 (42)
|
6471 (27)
|
19,929 (52)
|
|
Comorbidities, N (%)
|
|
History of arthrosis
|
21,475 (34)
|
5568 (23)
|
15,907 (41)
|
|
History of rheumatism
|
6111 (10)
|
2400 (10)
|
3711 (10)
|
|
History of arthritis
|
888 (1)
|
248 (1)
|
640 (2)
|
|
History of polyarthritis
|
2375 (4)
|
451 (2)
|
1924 (5)
|
|
History of spondyloarthritis
|
236 (1)
|
29 (1)
|
207 (1)
|
|
History of migraine
|
21,591 (35)
|
7073 (29)
|
14,518 (38)
|
