Fig. 3

Associations of NSAID recurrent use with breast cancer risk, compared to never/occasional use, in strata of selected factors, comorbidities, and recurrent¹ use of other drugs (E3N cohort, 2004–2014). Abbreviations: CI, confidence interval; BMI, body mass index; HR, hazard ratio; NSAID, nonsteroidal anti-inflammatory drug; MHT, menopause hormone therapy; PPI, proton pump inhibitor. ¹At least two reimbursements during any previous 3-month period since January 1, 2004. ²Adjusted for age (time scale) years of schooling (baseline), alcohol intake (time-varying), body mass index (time-varying), physical activity level (baseline), age at menarche (baseline), parity and age at first birth (baseline), lifetime use of oral contraceptives (baseline), age at menopause (baseline), history of breast cancer in first-degree relatives (baseline), personal history of benign breast disease (time-varying), lifetime use of menopausal hormone therapy (time-varying), and self-report of a mammogram performed during the previous follow-up cycle (time-varying). Categories used are those displayed in Table 1