Fig. 2

Phylogenetic tree as calculated by genetic distance of mutation haplotype between carriers. Two main mutation haplotypes exist among the mutation carriers, both of which encompass individuals from Iberia. Haplotype 1 harbors carriers from Colombia, Spain (predominantly from Catalonia), Angola, Portugal, and Brazil, while haplotype 2 harbors carriers from only Spain and Chile. An early recombination event in Spain likely occurred, as indicated by the two haplotypes sharing Spanish cases