Inflammatory marker | Breast Tanner stage | Relative change in breast composition per doubling of inflammatory marker | |||||
---|---|---|---|---|---|---|---|
Age-adjusted modelA | Age and body fatness-adjusted modelB | Multivariable-adjusted modelC | |||||
N | Estimate (95% CI) | N | Estimate (95% CI) | N | Estimate (95% CI) | ||
Total breast volume | |||||||
 CRP | Tanner 2 | 246 | 1.03 (1.00–1.06) | 245 | 1.01 (0.99–1.04) | 236 | 1.01 (0.99–1.04) |
Tanner 4 | 343 | 1.02 (1.00–1.05) | 343 | 0.98 (0.97–1.00) | 332 | 0.99 (0.97–1.01) | |
 IL-6 | Tanner 2 | 272 | 1.05 (1.00–1.10)* | 271 | 0.98 (0.94–1.02) | 262 | 0.98 (0.94–1.02) |
Tanner 4 | 341 | 1.10 (1.06–1.15)*** | 341 | 1.01 (0.97–1.04) | 330 | 1.01 (0.97–1.04) | |
 TNFR2 | Tanner 2 | 272 | 1.26 (1.07–1.48)** | 271 | 1.03 (0.90–1.18) | 262 | 1.07 (0.93–1.22) |
Tanner 4 | 341 | 1.35 (1.15–1.57)*** | 341 | 1.07 (0.95–1.20) | 330 | 1.06 (0.94–1.19) | |
Fibroglandular volume | |||||||
 CRP | Tanner 2 | 246 | 1.00 (0.97–1.03) | 245 | 1.00 (0.97–1.03) | 236 | 1.00 (0.98–1.03) |
Tanner 4 | 343 | 0.98 (0.96–1.00)* | 343 | 0.98 (0.96–1.00)* | 332 | 0.98 (0.96–1.01) | |
 IL-6 | Tanner 2 | 272 | 0.99 (0.95–1.03) | 271 | 0.99 (0.95–1.03) | 262 | 0.99 (0.95–1.04) |
Tanner 4 | 341 | 1.00 (0.96–1.04) | 341 | 1.00 (0.96–1.04) | 330 | 1.01 (0.96–1.05) | |
 TNFR2 | Tanner 2 | 272 | 0.98 (0.85–1.13) | 271 | 0.98 (0.85–1.14) | 262 | 1.01 (0.87–1.17) |
Tanner 4 | 341 | 1.06 (0.92–1.21) | 341 | 1.06 (0.92–1.23) | 330 | 1.04 (0.91–1.20) | |
Percent fibroglandular volume | |||||||
 CRP | Tanner 2 | 246 | 0.97 (0.95–0.99)* | 245 | 0.99 (0.97–1.01) | 236 | 0.99 (0.97–1.01) |
Tanner 4 | 343 | 0.96 (0.94–0.98)*** | 343 | 0.99 (0.98–1.01) | 332 | 1.00 (0.98–1.01) | |
 IL-6 | Tanner 2 | 272 | 0.94 (0.90–0.98)** | 271 | 1.01 (0.98–1.04) | 262 | 1.01 (0.98–1.05) |
Tanner 4 | 341 | 0.90 (0.87–0.94)*** | 341 | 1.00 (0.97–1.02) | 330 | 1.00 (0.97–1.02) | |
 TNFR2 | Tanner 2 | 272 | 0.78 (0.68–0.90)*** | 271 | 0.95 (0.86–1.05) | 262 | 0.95 (0.85–1.05) |
Tanner 4 | 341 | 0.78 (0.68–0.90)*** | 341 | 1.00 (0.91–1.09) | 330 | 0.98 (0.90–1.08) |