Skip to main content

Table 2 Association of inflammatory markers measured at Tanner 2 and Tanner 4 with breast composition measured at Tanner 4

From: Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche

Inflammatory marker

Breast Tanner stage

Relative change in breast composition per doubling of inflammatory marker

Age-adjusted modelA

Age and body fatness-adjusted modelB

Multivariable-adjusted modelC

N

Estimate (95% CI)

N

Estimate (95% CI)

N

Estimate (95% CI)

Total breast volume

 CRP

Tanner 2

246

1.03 (1.00–1.06)

245

1.01 (0.99–1.04)

236

1.01 (0.99–1.04)

Tanner 4

343

1.02 (1.00–1.05)

343

0.98 (0.97–1.00)

332

0.99 (0.97–1.01)

 IL-6

Tanner 2

272

1.05 (1.00–1.10)*

271

0.98 (0.94–1.02)

262

0.98 (0.94–1.02)

Tanner 4

341

1.10 (1.06–1.15)***

341

1.01 (0.97–1.04)

330

1.01 (0.97–1.04)

 TNFR2

Tanner 2

272

1.26 (1.07–1.48)**

271

1.03 (0.90–1.18)

262

1.07 (0.93–1.22)

Tanner 4

341

1.35 (1.15–1.57)***

341

1.07 (0.95–1.20)

330

1.06 (0.94–1.19)

Fibroglandular volume

 CRP

Tanner 2

246

1.00 (0.97–1.03)

245

1.00 (0.97–1.03)

236

1.00 (0.98–1.03)

Tanner 4

343

0.98 (0.96–1.00)*

343

0.98 (0.96–1.00)*

332

0.98 (0.96–1.01)

 IL-6

Tanner 2

272

0.99 (0.95–1.03)

271

0.99 (0.95–1.03)

262

0.99 (0.95–1.04)

Tanner 4

341

1.00 (0.96–1.04)

341

1.00 (0.96–1.04)

330

1.01 (0.96–1.05)

 TNFR2

Tanner 2

272

0.98 (0.85–1.13)

271

0.98 (0.85–1.14)

262

1.01 (0.87–1.17)

Tanner 4

341

1.06 (0.92–1.21)

341

1.06 (0.92–1.23)

330

1.04 (0.91–1.20)

Percent fibroglandular volume

 CRP

Tanner 2

246

0.97 (0.95–0.99)*

245

0.99 (0.97–1.01)

236

0.99 (0.97–1.01)

Tanner 4

343

0.96 (0.94–0.98)***

343

0.99 (0.98–1.01)

332

1.00 (0.98–1.01)

 IL-6

Tanner 2

272

0.94 (0.90–0.98)**

271

1.01 (0.98–1.04)

262

1.01 (0.98–1.05)

Tanner 4

341

0.90 (0.87–0.94)***

341

1.00 (0.97–1.02)

330

1.00 (0.97–1.02)

 TNFR2

Tanner 2

272

0.78 (0.68–0.90)***

271

0.95 (0.86–1.05)

262

0.95 (0.85–1.05)

Tanner 4

341

0.78 (0.68–0.90)***

341

1.00 (0.91–1.09)

330

0.98 (0.90–1.08)

  1. ALinear regression model adjusting for age at inflammatory biomarker measurement
  2. BModel adjusting for age at inflammatory biomarker measurement and fat percentage at biomarker measurement
  3. CModel adjusting for age at inflammatory biomarker measurement, fat percentage at biomarker measurement, ethnicity, birth weight, height age- and sex-specific Z-score, and maternal education
  4. *p < 0.05
  5. **p < 0.01
  6. ***p < 0.001